Original Article

European Journal of Clinical Nutrition (2006) 60, 991–999. doi:10.1038/sj.ejcn.1602410; published online 15 February 2006

Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD

Guarantors: HJ Schünemann and HM Ochs-Balcom.

Contributors: HMO-B contributed to the data acquisition, data analysis, data interpretation and manuscript preparation. BJBG contributed to the data interpretation, statistical supervision and review of the final draft. PM participated in design, funding, data interpretation and review of the final draft. CTS contributed to the statistical supervision, data interpretation and review of the final draft. JLF participated in design, funding, helped with data interpretation, review of the final draft. RWB measured the oxidative stress and antioxidant biomarkers, contributed to the data interpretation and review of the final draft. SEM contributed to the analysis of dietary antioxidant intakes, data interpretation and review of the final draft. MT participated in design, funding, data interpretation and review of the final draft. PAC contributed to the manuscript preparation and data interpretation. LI contributed to the data interpretation and review of the final draft. HJS contributed to the study design, data acquisition, funding, data analysis, data interpretation and manuscript preparation.

H M Ochs-Balcom1,2,3, B J B Grant1,4,5, P Muti1, C T Sempos1, J L Freudenheim1, R W Browne6, S E McCann7, M Trevisan1, P A Cassano8, L Iacoviello9 and H J Schünemann1,5,10,11

  1. 1Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
  2. 2Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
  3. 3Ireland Comprehensive Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA
  4. 4Section of Pulmonary, Critical Care, and Sleep Medicine, Veterans Administration Medical Center, Buffalo, NY, USA
  5. 5Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
  6. 6Department of Clinical Laboratory Science, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
  7. 7Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, NY, USA
  8. 8Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
  9. 9Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobosso, Italy
  10. 10Department of Epidemiology, National Cancer Institute Regina Elena, Rome, Italy
  11. 11Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

Correspondence: Dr HJ Schünemann, Italian National Cancer Institute, Rome Istituto Regina Elena, Via Elio Chianesi 53, 00144 Rome, Italy. E-mail: schuneh@mcmaster.ca or schunemann@ifo.it

Received 20 May 2005; Revised 7 November 2005; Accepted 22 November 2005; Published online 15 February 2006.

Top

Abstract

Objective:

 

The objective of this study was to investigate the association between antioxidant nutrients and markers of oxidative stress with pulmonary function in persons with chronic airflow limitation.

Design:

 

Cross-sectional study exploring the association of antioxidant nutrients and markers of oxidative stress with forced expiratory volume in the first second (FEV1%) and forced vital capacity (FVC%).

Setting/Subjects:

 

The study data included 218 persons with chronic airflow limitation recruited randomly from the general population of Erie and Niagara counties, New York State, USA.

Results:

 

After adjustment for covariates, multiple linear regression analysis showed that serum beta-cryptoxanthin, lutein/zeaxanthin, and retinol, and dietary beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, vitamin C, and lycopene were positively associated with FEV1% (P<0.05, all associations). Serum vitamins beta-cryptoxanthin, lutein/zeaxanthin, and lycopene, and dietary beta-cryptoxanthin, beta-carotene, vitamin C, and lutein/zeaxanthin were positively associated with FVC% (P<0.05, all associations). Erythrocytic glutathione was negatively associated with FEV1%, while plasma thiobarbituric acid-reactive substances (TBARS) were negatively associated with FVC% (P<0.05).

Conclusion:

 

These results support the hypothesis that an imbalance in antioxidant/oxidant status is associated with chronic airflow limitation, and that dietary habits and/or oxidative stress play contributing roles.

Keywords:

forced expiratory volume, vital capacity, glutathione, glutathione peroxidase, oxidative stress, TBARS

Extra navigation

.

naturejobs

More science jobs
Post a job for free
ADVERTISEMENT