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  • Original Article
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Mother's iron status, breastmilk iron and lactoferrin – are they related?

European Journal of Clinical Nutrition volume 60, pages 903–908 (2006)Cite this article

Abstract

Objective:

Exclusive breastfeeding is recommended till 6 months age. Factors regulating the breastmilk iron and lactoferrin levels are incompletely known. Considering high prevalence of nutritional anemia in lactating mothers, we studied the iron status of lactating mothers, their breastmilk iron and lactoferrin levels to determine any relationship between them.

Design:

Prospective study with 6 months follow-up.

Setting:

Tertiary care referral hospital.

Subjects:

Hundred nonanemic and 100 anemic mothers with their babies recruited at birth. Fifty-two nonanemic and 50 anemic mothers and their babies completed the 6-month follow-up.

Interventions:

Hemoglobin (Hb), total iron binding capacity (TIBC), percent transferrin saturation (%TS), serum iron (SI) and serum ferritin measured on day 1 and 6 months postpartum. Breastmilk iron and lactoferrin measured on day 1, 14 weeks and 6 months after delivery.

Results:

Breastmilk iron decreased progressively from day 1 to 14 weeks and at 6 months in both groups, but no significant difference was noted between nonanemic and anemic mothers (P>0.05). Significant decline in breastmilk lactoferrin concentration from day 1 to 14 weeks in nonanemic and anemic mothers (P<0.001) noted. Hemoglobin, TIBC, %TS, SI and serum ferritin of both groups had no correlation with breastmilk iron and lactoferrin concentration on day 1, 14 weeks and 6 months after delivery.

Conclusions:

Breastmilk iron and lactoferrin concentration had no relationship with the mother's Hb and iron status.

Sponsorship:

This work was carried out as part of thesis research under University of Delhi.

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References

  • Celada A, Brusset R, Guiterrez J, Herreros V (1982). No correlation between iron concentration in breastmilk and maternal iron stores. Helv Pediatr Acta 37 (1), 11–16.

    CAS  Google Scholar 

  • Clegg MS, Keen CL, Lonnerdal B, Hurley LS (1981). Influence of ashing techniques on the analysis of trace elements in animal samples. Biol Trace Elem Res 3, 107–115.

    Article  CAS  Google Scholar 

  • Curran JS, Barness LA (2004). The feeding of infants and children. In: Behrman RE, Kleigman RM, Jenson HB (ed). Nelson Textbook of Pediatrics. WB Saunders: Philadelphia. pp 149–169.

    Google Scholar 

  • Feeley RM, Eitenmiller RR, Jones Jr JB, Barnhart H (1983). Copper, iron and zinc contents of human milk at early stages of lactation. Am J Clin Nutr 37, 443–448.

    Article  CAS  Google Scholar 

  • Fransson GB, Lonnerdal B (1980). Iron in human milk. J Pediatr 96, 380–384.

    Article  CAS  Google Scholar 

  • Fransson GB, Agarwal KN, Gebre-Medhin M, Hambreus L (1985). Increased breastmilk iron in severe maternal anemia: physiological ‘trapping’ or leakage? Acta Paediatr Scand 74, 290–291.

    Article  CAS  Google Scholar 

  • Hall B (1979). Uniformity of human milk. Am J Clin Nutr 32, 304–312.

    Article  CAS  Google Scholar 

  • Houghton MR, Gracey M, Burke V, Bottrell C, Spargo RM (1985). Breastmilk lactoferrin levels in relation to maternal nutritional status. J Pediatr Gastroenterol Nutr 4, 230–233.

    Article  CAS  Google Scholar 

  • Hurley LS, Lonnerdal B (1988). Trace elements in human milk. In: Hanson L, (ed). Biology of Human Milk. Raven Press: New York. pp 75–94.

    Google Scholar 

  • International Committee for Standardization in Hematology (1978). The measurement of total and unsaturated iron-binding capacity in serum. Br J Hematol 38, 281–287.

  • International Committee for Standardization in Hematology (Expert Panel of Iron) (1990). Revised recommendations for the measurement of serum iron in human blood. Br J Hematol 75, 615–616.

  • Khurana V, Agarwal KN, Gupta S (1970). Iron content of breastmilk. Indian Pediatr 7, 659–661.

    CAS  PubMed  Google Scholar 

  • Krebs NF, Hambidge KM, Jacobs MA, Myleyt S (1985). Zinc in human milk: diurnal and within-feed patterns. J Pediatr Gastroenterol Nutr 4, 227–229.

    Article  CAS  Google Scholar 

  • Lauber E, Reinhardt M (1979). Studies on the quality of breastmilk during 23 months of lactation in a rural community of the Ivory Coast. Am J Clin Nutr 32, 1159–1173.

    Article  CAS  Google Scholar 

  • Lemons JA, Moye L, Hall D, Sommons M (1982). Differences in the composition of preterm and term human milk during early lactation. Pediatr Res 16, 113–117.

    Article  CAS  Google Scholar 

  • Loh TT, Sinnathuray TA (1971). Haematological data and milk iron in Malaysian women. Aust NZ J Obstet Gynaecol 11, 254–258.

    Article  CAS  Google Scholar 

  • Lonnerdal B (1984). Iron content in breast milk. In: Stekel A (ed). Iron Nutrition in Infancy and Childhood. Raven Press: New York. pp 95–117.

    Google Scholar 

  • Lonnerdal B, Forsum E, Gebre-Medhin M, Hambraeus L (1976). Breastmilk composition in Ethiopian and Swedish mothers. II. Lactose, nitrogen and protein content. Am J Clin Nutr 29, 1134–1141.

    Article  CAS  Google Scholar 

  • Murray MJ, Murray AB, Murray NJ, Murray MB (1978). The effect of iron status of Nigerian mothers on that of their infants at birth and 6 months, and on the concentration of Fe in breastmilk. Br J Nutr 39, 627–630.

    Article  CAS  Google Scholar 

  • NFHS (2000). India 1998–99 – National Family Health Suvey-2 (NFHS-2) – key findings: anemia among women and children. International Institute for Population Sciences, Mumbai, 19.

  • Picciano MF (2001). Nutrient composition of human milk. Pediatr Clin N Am 48, 53–67.

    Article  CAS  Google Scholar 

  • Picciano MF, Guthrie HA (1976). Copper, iron and zinc contents of mature human milk. Am J Clin Nutr 29, 242–254.

    Article  CAS  Google Scholar 

  • Sigman M, Lonnerdal B (1990a). Characterisation of transferrin recepters on plasma membranes of lactating rat mammary tissue. J Nutr Biochem 1, 239–243.

    Article  CAS  Google Scholar 

  • Sigman M, Lonnerdal B (1990b). Response of rat mammary gland transferrin receptors to maternal dietary iron during pregnancy and lactation. Am J Clin Nutr 52, 446–450.

    Article  CAS  Google Scholar 

  • Simes MA, Vouri E, Kuitunen P (1979). Breastmilk iron a declining concentration during the course of lactation. Acta Pediatr Scand 68, 29–31.

    Article  Google Scholar 

  • Smith AM, Picciano MF, Milner JA (1982). Selenium intakes and status of human milk and formula fed infants. Am J Clin Nutr 35 (3), 521–526.

    Article  CAS  Google Scholar 

  • Vanderhaar BK, Ziska SE (1989). Hormonal regulation of milk protein gene expression. Ann Rev Physiol 51, 641–652.

    Article  Google Scholar 

  • WHO (2001). Optimal duration of exclusive breastfeeding. WHO A54/INF Doc/4, 1.

  • Zavaleta N, Nombera J, Rojas R, Hambraeus L, Gislason J, Lonnerdal B (1995). Iron and lactoferrin in milk of anemic mothers given iron supplements. Nutr Res 15 (5), 681–690.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatology, University College of Medical Sciences and National Institute of Immunology, New Delhi, India

    Shashiraj, M M A Faridi, O Singh & U Rusia

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  1. Shashiraj
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  2. M M A Faridi
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  3. O Singh
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  4. U Rusia
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Correspondence to M M A Faridi.

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Guarantor: MMAF stands as guarantor and accountable for all parts of the completed manuscript, before and after publication.

Contributors: Shashiraj was the principal investigator and wrote the manuscript. MMAF designed the study, was the principal supervisor and contributed to the manuscript. OS analysed the breastmilk results and contributed to the manuscript. UR analyzed the hematology results and contributed to the manuscript.

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Shashiraj, Faridi, M., Singh, O. et al. Mother's iron status, breastmilk iron and lactoferrin – are they related?. Eur J Clin Nutr 60, 903–908 (2006). https://doi.org/10.1038/sj.ejcn.1602398

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