Original Article
European Journal of Clinical Nutrition (2006) 60, 610–613. doi:10.1038/sj.ejcn.1602358; published online 4 January 2006
Coffee drinking and risk of preterm birth
Guarantor: F Parazzini.
Contributors: FP was the principal investigator of the study giving the study hypothesis and planning the study design, FC and LC analysed the data, FC and FP drafted the paper, ER and VC assisted in analyses and writing, LF contributed to the conception and design of the study, LT and CM was involved in the baseline surveys for the study, LC took part in planning the study and interpreting the data and commented on the manuscript.
F Chiaffarino1, F Parazzini1,2, L Chatenoud1, E Ricci1, L Tozzi2, V Chiantera1, C Maffioletti2 and L Fedele3
- 1Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy
- 2I Clinica Ostetrico Ginecologica, Università di Milano, Milan, Italy
- 3Clinica Ostetrico Ginecologica, Università di Milano, Ospedale S. Paolo, Milan, Italy
Correspondence: Dr F Chiaffarino, Istituto di Ricerche Farmacologiche 'Mario Negri', Via Eritrea, 62 – 20157 Milano, Italy. E-mail: chiaffarino@marionegri.it
Received 27 October 2004; Revised 12 October 2005; Accepted 17 October 2005; Published online 4 January 2006.
Abstract
Objectives:
We analysed the association between coffee drinking before and during the three trimesters of pregnancy and the risk of preterm birth of babies normal for gestational age (NGA) or small for gestational age (SGA).
Methods:
Case–control study conducted in University clinics of North Italy. Cases were 502 women who delivered at <37 weeks of gestation. The controls included 1966 women who gave birth at term (
37 weeks of gestation) to healthy infants on randomly selected days at the hospitals where cases had been identified.
Results:
There was inverse association for coffee consumption in the third trimester of pregnancy in SGA cases compared to NGA (heterogeneity test between OR: 
12=5.6811 P<0.05). In comparison with not drinkers, all the ORs of overall intake of caffeine were closed near the unity for both SGA and NGA preterm birth.
Conclusion:
Compared with no consumption, a low consumption of coffee during pregnancy may not have significant effects on preterm birth.
Keywords:
coffee, preterm birth, risk factors, epidemiology, small for gestational age, normal for gestational age
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