Abstract
Objective:
The purpose of this study was to determine whether supplements of plant sterols and/or glucomannan improve lipid profile and cholesterol biosynthesis in mildly hypercholesterolemic type II diabetic and non-diabetic subjects and to compare the response of these two subject groups to the treatments.
Design:
A randomized, crossover study consisting of four phases of 21 days, with each phase separated by a 28-day washout.
Setting:
The Mary Emily Clinical Nutrition Research Unit of McGill University.
Subjects:
Eighteen non-diabetic individuals and 16 type II diabetic individuals aged 38–74 years.
Interventions:
Subjects were supplemented with plant sterols (1.8 g/day), glucomannan (10 g/day), a combination of glucomannan and plant sterols, and a placebo, provided in the form of bars.
Results:
Overall plasma cholesterol concentrations were lowered (P<0.05) after combination treatment (4.72±0.20 mmol/l) compared to control (5.47±0.18 mmol/l). Plasma low-density lipoprotein (LDL) cholesterol concentrations were decreased (P<0.05) after glucomannan (3.16±0.14 mmol/l) and combination treatments (2.95±0.16 mmol/l) compared to control (3.60±0.16 mmol/l). The results of lipid profiles did not differ between subject groups. Overall plasma lathosterol concentrations, an index of cholesterol biosynthesis, were lowered (P<0.05) after the combination treatment compared to the plant sterol treatment.
Conclusions:
The results suggest that glucomannan and a combination of glucomannan and plant sterols substantially improves plasma LDL cholesterol concentrations.
Sponsorship:
Forbes Medi-Tech Inc., Vancouver, British Columbia, Canada.
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Acknowledgements
We thank Christine Gurekian, Mira Laza and Dr Yanwen Wang for their assistance in conducting the clinical trial, the preparation of the tested bars, and the manuscript preparation.
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Yoshida, M., Vanstone, C., Parsons, W. et al. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur J Clin Nutr 60, 529–537 (2006). https://doi.org/10.1038/sj.ejcn.1602347
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DOI: https://doi.org/10.1038/sj.ejcn.1602347
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