Original Article
European Journal of Clinical Nutrition (2006) 60, 464–468. doi:10.1038/sj.ejcn.1602338; published online 7 December 2005
Effects of probiotics on the severity of experimental acute pancreatitis
M A T Muftuoglu1, S Isikgor1, S Tosun2 and A Saglam1
- 1The Fourth General Surgical Department of Haydarpasa Numune Teaching and Training Hospital, Uskudar, Istanbul, Turkey
- 2Pathology Department of Haydarpasa Numune Teaching and Training Hospital, Uskudar, Istanbul, Turkey
Correspondence: Dr MAT Muftuoglu, Mustafa Mazhar Bey Sok. 11/3, Onalanlar Ap, Feneryolu, 34724, Kadikoy/Istanbul, Turkey. E-mail: tmuftuoglu@ttnet.net.tr
Received 13 April 2005; Revised 16 August 2005; Accepted 14 September 2005; Published online 7 December 2005.
Abstract
Objective:
This study was designed to evaluate the effects of probiotics on the severity of experimental acute pancreatitis.
Design:
Experimental study.
Setting:
Experiments were done in a laboratory at Haydarpasa Numune Teaching and Research Hospital.
Subjects:
A total of 50 Wistar rats were randomly divided into five groups.
Interventions:
Group 1 was control group. Group 2 received an intraperitoneal injection of a 20% solution in 0.15 mol/l NaCL. Group 3 was injected NaCL and fed with probiotics. Acute pancreatitis was induced in rats by intrperitoneal injection of L-Arginine in groups 4 and 5. The rats in group 5 were treated with probiotics. The pancreas was removed for histologic examination. Evaluation of the pathologic changes was done by a new combined histopathologic grading scale.
Results:
The mean scores of fibrosis, acinar cell loss, oedema, parenchymal necrosis, mononuclear cells infiltration, polymorphonuclear leucocytes infiltration, ductal damage and atypical reactive regeneration in group 5 were significantly lower than group 4.
Conclusions:
We demonstrated that enteral feedings with added probiotics can reduce the severity of acute pancreatitis.
Sponsorship:
None.
Keywords:
enteral feeding, probiotics, acute pancreatitis
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