Short Communication
European Journal of Clinical Nutrition (2005) 59, 801–804. doi:10.1038/sj.ejcn.1602142 Published online 27 April 2005
Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype
Guarantor: B Lamarche.
Contributors: AC was responsible for characterization of the LDL by PAGE, for data analysis and redaction of the article under the supervision and in the laboratory of BL. PJH designed and conducted the intervention study at McGill University. CAV and MPSO contributed to the study design and managed the dietary intervention. WP monitored the participants during the study. All contributors approved the manuscript.
A Charest1, C Vanstone2, M P St-Onge2, W Parson2, P J H Jones1,2 and B Lamarche1
- 1Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada
- 2School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Québec, Canada
Correspondence: B Lamarche, Institute on Nutraceuticals and Functional Foods, Pavillon des Services, Office 2742, Laval University, Ste-Foy, Québec, Canada G1K 7P4. E-mail: benoit.lamarche@inaf.ulaval.ca
Received 2 February 2004; Revised 20 December 2004; Accepted 17 February 2005; Published online 27 April 2005.
Abstract
Objective:
To examine the impact of nonfat and low-fat phytosterol-enriched beverages on low-density lipoprotein (LDL) electrophoretic characteristics.
Design:
Double-blind, randomized, crossover, placebo-controlled dietary trial.
Setting:
Diets were prepared and consumed at the Mary Emily Clinical Nutrition Research Unit of McGill University. Analyses were performed at the Institute on Nutraceuticals and Functional Foods of Laval University.
Subjects and intervention:
In total, 15 moderately hypercholesterolemic persons consumed each of three experimental diets that each comprised a different beverage: nonfat placebo (NF control), nonfat with phytosterols (NFPS) or low-fat with phytosterols (LFPS). Participants consumed three beverages daily at meal time for a total of 1.8 g of phytosterols per day. Nondenaturing 2–16% polyacrylamide gradient gel electrophoreses were used to characterize LDL size characteristics.
Results:
The NFPS and LFPS beverage induced no significant changes in several features of the LDL size phenotype compared to the control diet.
Conclusion:
The consumption of phytosterol-supplemented nonfat and low-fat beverages is not associated with clinically meaningful changes in the LDL particle size phenotype.
Sponsorship:
This study was supported partly by the Canada Research Chair in Nutrition, Functional Foods and Cardiovascular Health (B Lamarche) and by the Dairy Farmers of Canada.
Keywords:
Coronary heart disease, phytosterols, beverage, small, dense LDL
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