Short Communication
European Journal of Clinical Nutrition (2005) 59, 456–458. doi:10.1038/sj.ejcn.1602081 Published online 10 November 2004
Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study
Guarantor: J-I Kim.
Contributors: JCK was involved in study design. J-IK contributed to the practical organization of the trial. M-JK and M-SL were responsible for biochemical analyses. J-JK was responsible for design and statistical analyses. I-JC was responsible for project management. JCK and J-IK wrote the first draft of the paper and all authors contributed to the final draft.
J -I Kim1, J C Kim2, M -J Kang1, M -S Lee3, J -J Kim4 and I -J Cha5
- 1Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Institute of Basic Sciences, Inje University, Gimhae, Republic of Korea
- 2School of Food and Life Science, Institute for Food Sciences, Institute for Basic Sciences, Inje University, Gimhae, Republic of Korea
- 3School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Republic of Korea
- 4Department of Microbiology, College of Agriculture, Gyeongsang National University, Jinju, Republic of Korea
- 5Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Pusan, Republic of Korea
Correspondence: JC Kim, School of Food and Life Science, Institute for Food Sciences, Institute for Basic Sciences, Inje University, Obang dong 607, Gimhae 621-749, Republic of Korea. E-mail: jckim@inje.ac.kr
Received 22 March 2004; Revised 27 July 2004; Accepted 20 September 2004; Published online 10 November 2004.
Abstract
Objective:
To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.
Design:
Randomized, double-blind, placebo-controlled, parallel-group trial.
Setting:
Pusan Paik Hospital, Pusan, Republic of Korea.
Interventions:
A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.
Results:
Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).
Conclusions:
These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.
Sponsorship:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (HMP 02-PJ1-PG3-22005-0011).
Keywords:
pinitol (3-O-methyl-D-chiro-inositol), type II diabetes mellitus, soy, glucose, glycated haemoglobin, cholesterol
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