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Plasma coagulation factor VII activity and its correlates in healthy men

European Journal of Clinical Nutrition volume 59, pages 1423–1428 (2005)Cite this article

Abstract

Objective:

The aim of this study was to investigate the plasma coagulation factor VII activity and its correlates in healthy Australian men.

Design:

Cross-sectional study.

Setting:

Free living subjects.

Subjects:

A total of 139 healthy Australian males aged 20–55 y with widely varying intakes of individual fatty acids.

Outcome measures:

The concentration of phospholipid fatty acids and the parameters of biochemistry were analysed by standard methods. Citrated plasma factor VII activity was measured by using the ACL 200 system with commercially available kits.

Results:

In the stepwise multiple regression, controlled for age, body mass index and dietary groups, the two most important variables of factor VII activity were selected in the forward entry model with R2=0.474 and P<0.0001 from 19 independent variables, which were significantly correlated with plasma factor VII activity in age-adjusted bivariate analysis where significance was considered at P<0.01. Plasma factor VII activity was strongly negatively correlated with prothrombin time (PT) (Std. Coeff. −0.550), and significantly positively correlated with plasma phospholipid (PL) stearic acid (Std. Coeff. 0.285).

Conclusions:

Increased factor VII activity was associated with shortening of PT. All types of fatty-acid concentrations of PLs were significantly positively correlated with factor VII activity; however, stearic acid was more potent than other fatty acids in healthy Australian men.

Sponsorship:

Meat Research Corporation of Australia.

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Acknowledgements

We thank Neil Mann, Fiona Kelly, Lavinia Abedin, Leeann Johnson, They Ng, Alisa Wilson and Sirithon Nakkote for their assistance.

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Authors and Affiliations

  1. Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China

    D Li

  2. School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia

    A Turner

  3. Department of Food Science, RMIT University, Melbourne, Victoria, Australia

    A J Sinclair

Authors
  1. D Li
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  2. A Turner
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  3. A J Sinclair
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Corresponding author

Correspondence to D Li.

Additional information

Guarantor: AJ Sinclair.

Contributors: DL, AJS and AT initiated the study. DL prepared the drafts of the paper, did laboratory assays, collected data and did the statistical analysis. AJS selected the study site, supervised the project and secured the funding. All investigators contributed to the interpretation of data and to paper preparation.

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Li, D., Turner, A. & Sinclair, A. Plasma coagulation factor VII activity and its correlates in healthy men. Eur J Clin Nutr 59, 1423–1428 (2005). https://doi.org/10.1038/sj.ejcn.1602257

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  • DOI: https://doi.org/10.1038/sj.ejcn.1602257

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