Original Communication
European Journal of Clinical Nutrition (2005) 59, 1142–1148. doi:10.1038/sj.ejcn.1602224; published online 13 July 2005
A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet
J C L Mamo1, A P James1, M J Soares1, D G Griffiths1, K Purcell1 and J L Schwenke1
1School of Public Health, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Perth, Australia
Correspondence: JCL Mamo, School of Public Health, Curtin University of Technology, GPO Box U1987, Perth 6845, Australia. E-mail: J.Mamo@curtin.edu.au
Received 22 November 2004; Revised 5 May 2005; Accepted 25 May 2005; Published online 13 July 2005.
Abstract
Objective:
To investigate whether altering energy intake as red meat protein or carbohydrate modifies chylomicron homeostasis and postprandial lipaemia.
Design:
Randomized single-blind dietary intervention trial.
Setting:
School of Public Health, Division of Health Science, Curtin University, Perth, Western Australia.
Subjects:
A total of 20 moderately hypertriglyceridaemic but otherwise healthy subjects were recruited and completed the study.
Intervention:
Participants consumed an isocaloric weight maintenance diet low in protein (14, 53 and 30% of energy as protein, carbohydrate and fat, respectively) or high in protein (25, 35 and 30% energy as protein, carbohydrate and fat) for a period of 6 weeks. Fasting plasma lipids and postprandial lipoprotein studies (triglyceride and apolipoprotein B48) following an oral fat challenge were carried out at the start and conclusion of the dietary intervention period.
Results:
Consumption of the low- or high-protein diet had no significant effect on fasting plasma or postprandial lipaemia, the latter determined as the incremental area under the triglyceride curve following a fat challenge. However, subjects who consumed a low-protein diet for 6 weeks had a substantially exaggerated postprandial chylomicron response, indicated as the area under the apo B48 curve following a fat challenge. The change in postprandial chylomicron kinetics could not be explained by changes in insulin sensitivity, which appeared to be similar before and after intervention with either diet.
Conclusions:
Daily moderate consumption of a lean red meat protein-enriched diet attenuates postprandial chylomicronaemia in response to ingestion of a fatty meal.
Sponsorship:
Meat and Livestock, Australia.
Keywords:
lipid metabolism, postprandial lipoproteins, chylomicrons, apolipoprotein B48, carbohydrate, protein
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