Short Communication
European Journal of Clinical Nutrition (2005) 59, 152–154. doi:10.1038/sj.ejcn.1602039 Published online 15 September 2004
Malnutrition in adults with cystic fibrosis
Guarantor: D Hubert.
Contributors: XD collected most of the data, performed the statistical analysis and wrote the first version of the manuscript. RK participated in collecting additional data. TB performed the genetic molecular analysis. TB and DH classified the CFTR genotypes, DH, ND-D, DD enrolled and followed the patients as referent physicians for the respiratory manifestations of the disease. PM was the referent physician for the digestive complications of cystic fibrosis. All authors contributed to the editorial improvement of the manuscript.
X Dray1, R Kanaan2, T Bienvenu3, N Desmazes-Dufeu2, D Dusser2, P Marteau1 and D Hubert2
- 1Service d'Hépato-Gastro-Entérologie, Hôpital Européen Georges Pompidou, Paris
- 2Service de Pneumologie, Hôpital Cochin, Paris
- 3Service de Biochimie et Génétique Moléculaire, Hôpital Cochin, Paris
Correspondence: D Hubert, Service de Pneumologie, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75679 Paris cedex 14, France. E-mail: dominique.hubert@cch.ap-hop-paris.fr
Received 11 October 2003; Revised 1 April 2004; Accepted 15 June 2004; Published online 15 September 2004.
Abstract
Objective: To determine the prevalence and clinical features of malnutrition and its relationship with the CFTR genotype in a cystic fibrosis (CF) adult population.
Design: Cross-sectional study.
Setting: Department of Pulmonology, Cochin Hospital, Paris, France.
Subjects: 163 CF adults seen between 1997 and 1999.
Results: Mean age was 28.8 y. Mean body mass index (BMI) was 19.1 kg/m2. Malnutrition (BMI<18.5 kg/m2) was seen in 81 patients (49.7%). Its severity was associated with diagnosis of CF before the age of 18 y (P<0.01), FEV1 values below 30% (P<0.01), the yearly decline of FEV1 (P<0.01), pancreatic insufficiency (P<0.01) and gastro-oesophageal reflux (P<0.01). Malnutrition was observed in 58.7% of patients with a severe CFTR genotype but in 28.6% of patients with a mild genotype (P<0.001).
Conclusion: Malnutrition remains frequent in adults with CF except in patients presenting with a mild CFTR genotype (leading to a mild phenotype and to later diagnosis).
Sponsorship: None.
Keywords:
cystic fibrosis, malnutrition
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