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Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus

European Journal of Clinical Nutrition volume 58, pages 1239–1247 (2004)Cite this article

Abstract

Background: The prevalence of type 2 diabetes mellitus (T2DM) is increasing with an epidemic growth rate. Animal studies with taurine supplementation have shown increased insulin secretion and action, suggesting that taurine supplementation may have a potential to prevent T2DM.

Objective: To assess the effect of taurine treatment on insulin secretion and action, and on plasma lipid levels in overweight men with a positive history of T2DM.

Design: 20 nondiabetic subjects were included in a double-blinded, randomized, crossover study, receiving a daily supplementation of 1.5 g taurine or placebo for two periods of 8 weeks. The subjects were overweight first-degree relatives of T2DM patients. An intravenous glucose tolerance test (IVGTT) was used to measure first-phase insulin secretory response, and a euglycemic hyperinsulinemic clamp was used to determine peripheral insulin action.

Results: Mean plasma taurine concentration was 39±7 (s.d.) μmol/l after placebo and 131±62 μmol/l after taurine intervention (P<0.0001). There was no significant difference after taurine intervention compared to placebo in incremental insulin response (Insincr.) neither during the IVGTT, nor in insulin-stimulated glucose disposal during the clamp. Insulin secretion, adjusted for insulin sensitivity, was also unchanged. There was no significant effect of taurine supplementation on blood lipid levels as well.

Conclusion: Daily supplementation with 1.5 g taurine for 8 weeks had no effect on insulin secretion or sensitivity, or on blood lipid levels. These findings in persons with an increased risk of T2DM are in contrast to those from animal studies, and do not support the assumption that dietary supplementation with taurine can be used to prevent the development of T2DM.

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Acknowledgements

We thank the subjects for their participation, and Marianne Modest, Stella Falster as well as the staff at Steno Diabetes Center for their contribution and hard work.

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  1. Contributed equally to this work.

Authors and Affiliations

  1. Steno Diabetes Center, Gentofte, Denmark

    C Brøns, C Spohr, H Storgaard & A Vaag

  2. Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

    C Brøns, C Spohr & J Dyerberg

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  1. C Brøns
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Contributions

Guarantors: C Brøns and C Spohr.

Contributors: Charlotte Brøns and Camilla Spohr were involved in the design of the study, collection and analysis of data, writing the manuscript. Heidi Storgaard assisted in the collection of data, commenting the article. Jørn Dyerberg and Allan Vaag were involved in design of the study, providing advice, commenting the article.

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Correspondence to C Brøns.

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The study was supported by grants from Steno Diabetes Center, Gentofte, Denmark and by Aase and Ejnar Danielsens Foundation, Lyngby, Denmark.

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Brøns, C., Spohr, C., Storgaard, H. et al. Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus. Eur J Clin Nutr 58, 1239–1247 (2004). https://doi.org/10.1038/sj.ejcn.1601955

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  • DOI: https://doi.org/10.1038/sj.ejcn.1601955

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