¹Maastricht University, Human Biology, Maastricht, The Netherlands

Correspondence: N.Vogels, Maastricht University, Human Biology, PO Box 616, 6200 MD Maastricht, The Netherlands. E-mail: N.Vogels@HB.Unimaas.NL

Received 14 March 2003; Revised 23 July 2003; Accepted 2 August 2003.

Abstract

Objective: Since grape-seed extract has been shown to stimulate lipolysis in vitro and reduce food intake in rats, we assessed the efficacy of grape-seed extract with respect to energy intake (EI) and satiety.

Design: In a randomized, placebo-controlled, double-blind, cross-over study, 51 subjects (age 18–65 y, body mass index 22–30 kg/m²) ate an ad libitum lunch and dinner twice in the University Restaurant for 3 days. Standard breakfasts and snacks were provided. Supplements were taken 30–60 min prior to each meal.

Results: In the total study population, no difference in 24 h EI was found between the grape-seed extract and placebo. However, in the subgroup of subjects (n=23) with an energy requirement the median of 7.5 MJ/day, EI was reduced by 4% (EI 352.1 kJ/24 h, P=0.05) after grape-seed extract compared to placebo treatment. Meanwhile, there were no significant differences in macronutrient composition, attitude towards eating, satiety, mood or tolerance.

Conclusions: Grape seed reduced 24 h EI, with on average 4% in subjects who had an energy requirement 7.5 MJ/day, without further effects on satiety, mood or tolerance. These findings suggest that grape seed could be effective in reducing 24 h EI in normal to overweight dietary unrestrained subjects, and could, therefore, play a significant role in body-weight management.