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| November 2001, Volume 55, Number 11, Pages 922-931 |
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| Original Communication |
| A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids |
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| E Södergren1, I-B Gustafsson2, S Basu1, J Nourooz-Zadeh3, C Nälsén1, A Turpeinen4, L Berglund1 and B Vessby1 |
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1Section for Geriatrics/Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
2Department of Culinary Arts, University of Örebro, Örebro, Sweden
3Division of Medicine, Department of Medicine, University College London, London, UK
4Department of Applied Chemistry and Microbiology, Division of Nutrition, University of Helsinki, Helsinki, Finland
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Correspondence to: E Södergren, Section for Geriatrics/Clinical Nutrition Research, Department of Public Health and Caring Science, Uppsala University, Uppsala, Sweden
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Guarantors: E Södergren and B Vessby. Contributors: ES organised the dietary intervention, analysed hydroperoxides and total F2-isoprostanes, co-ordinated data and drafted the manuscript. I-BG was involved in the study design and supervised the dietary intervention. SB performed the analyses of free F2-isoprostanes. CN did the analyses of antioxidative capacity. AT performed the analyses of thromboxanes. LB was involved in the study design and statistical analyses. BV was involved in the study design and provided advice during all stages of the study. All authors were involved in editing the manuscript. |
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| Abstract |
| Objective: To compare the effects of a rapeseed oil-based diet containing an increased proportion of easily oxidised polyunsaturated fatty acids such as  -linolenic acid with a diet rich in saturated fatty acids on the degree of lipid peroxidation in the human body. Design: A randomised cross-over study. Subjects and interventions: Nineteen healthy moderately hyperlipidemic subjects (six women and 13 men, age 50±8 y and body mass index (BMI) 24.5±2.6 kg/m2) were given a rapeseed oil-based diet (RO) and a control diet (SAT) rich in saturated fatty acids during two consecutive 4 week periods separated by a 4 week wash-out period. Biomarkers of lipid peroxidation and antioxidants were analysed in plasma and urine. Results: No significant differences in plasma or urinary levels of free 8-iso-prostaglandin F2 , plasma total 8-iso-prostaglandin F2 plasma hydroperoxides or plasma malondialdehyde were observed between the RO and SAT diets (P=0.14-0.95). A higher concentration of serum  -tocopherol was detected after the RO diet compared to the SAT diet (P<0.001), whereas the serum -tocopherol concentration and plasma antioxidative capacity did not differ between the two test diets. The total cholesterol, LDL cholesterol and LDL/HDL ratio were lower after the RO diet compared to the SAT diet (P<0.001), while HDL cholesterol and total triglyceride levels were similar after the two diets. Conclusion: These results suggest that a rapeseed oil-based diet rich in -linolenic acid does not seem to increase the degree of lipid peroxidation in plasma and urine compared to a diet rich in saturated fats. This is possibly due to a sufficient content of antioxidants in the rapeseed oil diet to increase circulating concentrations of antioxidants that may protect unsaturated fatty acids from oxidation. Sponsorship: Swedish Council for Forestry and Agricultural Research and Foundation for Geriatric Research. European Journal of Clinical Nutrition (2001) 55, 922-931 |
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| Keywords |
| rapeseed oil; lipid peroxidation; antioxidants; serum lipids |
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| Received 9 June 2000; revised 28 March 2001; accepted 30 March 2001 |
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| November 2001, Volume 55, Number 11, Pages 922-931 |
| Table of contents Previous Abstract Next Article PDF |
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