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| June 2000, Volume 54, Number 6, Pages 460-462 |
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| Original Communication |
| Serum albumin and colorectal cancer risk |
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| P Knekt1, T Hakulinen2,3, A Leino4, M Heliövaara1, A Reunanen1 and R Stevens5 |
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1National Public Health Institute, Helsinki, Finland
2Finnish Cancer Registry, Helsinki, Finland
3Department of Cancer Epidemiology, Radiumhemmet, Karolinska University Hospital, Stockholm, Sweden
4Social Insurance Institution, Helsinki and Turku, Finland
5University of Connecticut, Health Center, Framington, USA
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Correspondence to: P Knekt, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland.
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Guarantor: Dr P Knekt. Contributors: P Knekt supervised the project, carried out the statistical analyses and prepared the draft; T Hakulinen provided the cancer incidence data; A Leino carried out the laboratory analyses; M Heliövaara participated in planning of the study design; A Reunanen participated in the conduction of the baseline data; R Stevens initiated the study and contributed to the interpretation of the data. All investigators contributed to the paper. |
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| Abstract |
| Objective: To study the relationship between serum albumin and colorectal cancer occurrence. Design: A case-control study nested within a cohort followed from 1968 to 1991. Subjects and methods: The albumin concentration was determined from serum samples stored at -20°C at baseline in 177 incident colorectal cancer cases and 288 controls matched for sex, age and study region. Results: An elevated risk was present of cancer of the left, distal colon at high serum albumin concentrations. No significant association was observed for the right, proximal colon or the rectum. The relative risks of cancer of the distal and proximal colon among individuals in the highest and lowest quartiles of serum albumin were 17.03 (95% confidence interval 1.48-195) and 0.77 (95% confidence interval 0.19-3.13), respectively. Conclusions: The present study lends support to the hypothesis that some dietary factor associated with serum albumin may be a risk factor for distal colon cancer. Sponsorship: This study was supported by a grant from the Swedish Cancer Foundation. European Journal of Clinical Nutrition (2000) 54, 460-462 |
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| Keywords |
| albumin; antioxidant; cohort studies; colon; neoplasms; rectum |
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| Received 5 October 1999; revised 15 January 2000; accepted 17 January 2000 |
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| June 2000, Volume 54, Number 6, Pages 460-462 |
| Table of contents Previous Abstract Next Article PDF |
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