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Metastasis: Coming unstuck
Just as avoiding apoptosis is a crucial component of transformation, the ability to avoid apoptosis resulting from lack of adhesion seems to be required for metastasis.
24 September 2004 |
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Cardiovascular disease: Preventing the bubble bursting?
5-lipoxygenase is a potential therapeutic target for preventing life-threatening arterial ruptures that are often linked with atherosclerosis.
24 September 2004 |
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Epigenetics: Silent transmission
In mammals, DNA and histone methylation together provide an effective, long-term mechanism for silencing gene expression, but how specific methylation patterns are 'remembered' during cell division is unclear.
17 September 2004 |
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Pharmacogenomics: ABCs of drug resistance
Expression data for all human ABC transporters in cancer cells provides a valuable tool for improving understanding of drug resistance mediated by these proteins.
17 September 2004 |
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Pain: Less pain when you're in control?
Differences in perceived pain control influence the activation of the brain regions involved in pain processing.
17 September 2004 |
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Environmental microbiology: Pay dirt
Genomic analysis of uncultured soil bacteria has revealed antibiotic-resistance genes that are considerably different from previously reported sequences.
17 September 2004 |
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Therapeutics: Pinch hitter
The compound BMS-354825 seems to be even more potent than Iressa, and used together these drugs might offer the most powerful treatment yet for CML.
27 August 2004 |
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Antimalarials: Joint attack on malaria.
An international group of scientists, drawn from both academia and industry, has developed a new antimalarial drug candidate that will move into human clinical trials later this year.
27 August 2004 |
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Immunogenetics: KIRs resolve the issue
An inhibitory natural-killer-cell receptor and its ligand affect the outcome of infection with hepatitis C virus.
27 August 2004 |
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