Computational
chemistry: Sifting success
Integrating rigorously validated QSAR models with database mining
could be a valuable general tool in the design and discovery
of novel bioactive chemical entities. 28 May 2004
Systems
biology: Timing is everything
Experiments investigating the delicate regulation of amino-acid
synthesis in bacteria might be as important to the development
of systems biology as similarly experiments in E. coli were
to that of molecular biology and genetics. 28 May 2004
Cancer:
Proteins perish under spotlight
Proteomic-based screens have advantages over current high-throughput
genomic approaches in that they can unearth unexpected candidates
in processes such as tumour invasion. 28 May 2004
Targeted
therapies: Layers of necessity
Why the ABL tyrosine-kinase inhibitor imatinib (Glivec) is efficacious
in chronic myeloid leukaemia, but has little effect in BCR-ABL1-positive
B-cell acute lymphoblastic leukaemia. 14 May 2004
Respiratory
disease: Timing is everything
Beta-blockers, which are presently contraindicated for asthmatics,
might actually be able to prevent serious attacks. 7 May 2004
Therapeutics:Staying
on target
A gene-therapy approach specifically targets the endothelial
cells of the growing tumour vasculature without affecting normal
blood vessels. 7 May 2004
