Research highlights archive: April 2004

		Mouse model: Reconstruction clues Reconstruction of functionally normal and malignant human breast tissues in mice provides a more realistic model of breast cancer. 23 April 2004
		Viral pathogenesis: Strategic comparisons Transcriptomics reveals whether studies of viral pathogenesis in preclinical models can be extrapolated to humans. 23 April 2004
		Regulatory T cells: Reduction in regulation The first evidence that a defect in CD4+CD25hi TReg-cell function can be linked to an autoimmune disease in humans. 16 April 2004
		Immune evasion: HIV takes the indirect route HIV can also avoid detection by the immune system in an indirect manner to cytotoxic T lymphocyte escape which has important implications for HIV vaccine design. 16 April 2004
		Neurological disorders: Special agents provide early warnings Detect early changes in patients who are at risk of developing Alzheimer's disease through the non-invasive imaging of senile plaques might now be possible. 16 April 2004
		Regulatory T cells: Reduction in regulation The first evidence that a defect in CD4+CD25hi TReg-cell function can be linked to an autoimmune disease in humans. 16 April 2004
		Neurodegenerative disease: Linking lipids to Alzheimer's A new study establishes a link between amyloid peptide, oxidative stress and perturbed lipid metabolism in the pathogenesis of Alzheimer's disease. 8 April 2004
		Technology: Nanolab gets the rubber stamp A pocket laboratory the size of a postage stamp can carry out DNA purifications and potentially much more. 8 April 2004
		Vaccines: SPOT-on malaria target The difficulty of defining an immunological correlate of protection in humans from a malaria vaccine has been overcome. 8 April 2004
		Cardiovascular disease: Intensive care Not all statins are created equal. 5 April 2004
		Tumorigenesis: Hero or villain? Confusion about whether peroxisome-proliferator-activated receptor-γ has an inhibitory or stimulatory effect on tumorigenesis has been resolved. 5 April 2004
		Prions: New cattle TSE identified A new transmissible spongiform encephalopathy has been discovered in cattle. 5 April 2004