Therapeutics: It's suffocating in here!
YC-1 - originally developed for the treatment of circulatory disorders - can starve tumour cells of the oxygen that is required for growth and metastasis. 25 April 2003
Drug resistance: Sensitive to change
Resistance of ovarian cancer cell lines to cisplatin depends on the methylation status of one of the key genes in the DNA repair response pathway. 25 April 2003
Therapeutics: Breaking down resistance
An in vitro screen of BCR-ABL mutants has given a comprehensive picture of mutations that confer resistance to Gleevec. 17 April 2003
Angiogenesis: Culprits uncovered
The MYC and RAS oncogenes cooperate to initiate angiogenesis - a crucial step in tumour progression. 17 April 2003
ADME: Pressures in the pipeline
Comparing the physiochemical properties of marketed oral drugs with those in development reveals what pharmacokinetic properties will allow drugs to successfully go through the drug development pipeline. 11 April 2003
Biotechnology: Fingers in the genome pie
Two papers report new strategies for identifying zinc finger proteins for the construction of artificial transcription factors. 11 April 2003
Lead generation: Get a grip
A novel extension of dynamic combinatorial chemistry can generate nonpeptidic inhibitors of a key mediator of apoptosis. 7 April 2003
Cell biology of the neuron: FMRP and its many partners
Two studies give new insight into the possible functions of the protein FMRP, which is linked to fragile X syndrome, the most common cause of mental retardation. 7 April 2003
