Abstract
The SWI/SNF complex participates as a co-activator in the transcriptional regulation of certain genes. Conversely, we and others have recently established that Brg1 and Brm, the central components of SWI/SNF, act instead as co-repressors for E2F-mediated transcriptional repression, and for the transcription of certain other promoters. We report here that Brg-1 and Brm can switch their mode of function at same promoter between activation and repression by ligand-directed differential coordination with BAF155, BAF170, HDAC1, p300 and prohibitin. This ligand and context-dependent reprogramming of the SWI/SNF complex allows it to differentially serve as either a co-repressor or a co-activator of transcription at the same promoter.
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Acknowledgements
We thank Dr Srikumar P Chellappan for his continuous support. We thank Dr Junn Yanagisawa for reagents. This work was partially supported by grants from the National Cancer Institute (CA101992 and 1R03CA102940-01), and Susan G Komen Breast Cancer Foundation (BCTR0403163). SW is the recipient of the BUSM Department of Medicine Pilot Project Grant Award and an Aid for Cancer Research grant award.
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Zhang, B., Chambers, K., Faller, D. et al. Reprogramming of the SWI/SNF complex for co-activation or co-repression in prohibitin-mediated estrogen receptor regulation. Oncogene 26, 7153–7157 (2007). https://doi.org/10.1038/sj.onc.1210509
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DOI: https://doi.org/10.1038/sj.onc.1210509
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