Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

VSV-tumor selective replication and protein translation

Oncogene volume 24, pages 7710–7719 (2005)Cite this article

Abstract

The emergence of vesicular stomatatis virus (VSV) as a potent antitumor agent has made a dissection of the molecular determinants of host-cell permissiveness to this virus an important objective. Such insight would not only enable the intelligent design of future generations of recombinant VSV vectors to combat disease, but may also resolve general features of cellular transformation that may be exploited by this virus, and perhaps other oncolytic viruses. The defective pathways underlining the oncolytic activity of VSV remain to be fully determined but recent data indicates that flaws in innate immune responses, involving the interferon (IFN) system, may commonly occur in tumor cells and thus play a large role in facilitating oncolysis. Aside from the IFN system, however, it is almost certain that other key cellular pathways may be similarly defective and therefore cooperatively contribute towards mediating rapid oncolytic virus activity. Recent data have indicated that defects in cancer cell translational regulation could be one area that may be exploited by VSV. Certainly, all viruses require cellular protein synthesis pathways to facilitate their replication and many have devised numerous mechanisms to ensure that viral mRNAs become translated at the expense of the host. Using VSV as a model, this review will discuss some of the recent developments in the fields of innate immunity and translational regulation that may help explain mechanisms of viral oncolysis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  • Abbott CM and Proud CG . (2004). Trends Biochem. Sci., 29, 25–31.

  • Abraham N, Stojdl DF, Duncan PI, Methot N, Ishii T, Dube M, Vanderhyden BC, Atkins HL, Gray DA, McBurney MW, Koromilas AE, Brown EG, Sonenberg N and Bell JC . (1999). J. Biol. Chem., 274, 5953–5962.

  • Akira S and Takeda K . (2004). Nat. Rev. Immunol., 4, 499–511.

  • Balachandran S and Barber GN . (2000). IUBMB Life, 50, 135–138.

  • Balachandran S and Barber GN . (2004). Cancer Cell, 5, 51–65.

  • Balachandran S, Porosnicu M and Barber GN . (2001). J. Virol., 75, 3474–3479.

  • Balachandran S, Roberts PC, Brown LE, Truong H, Pattnaik AK, Archer DR and Barber GN . (2000a). Immunity, 13, 129–141.

  • Balachandran S, Roberts PC, Kipperman T, Bhalla KN, Compans RW, Archer DR and Barber GN . (2000b). J. Virol., 74, 1513–1523.

  • Balachandran S, Thomas E and Barber GN . (2004). Nature, 432, 401–405.

  • Ball LA, Pringle CR, Flanagan B, Perepelitsa VP and Wertz GW . (1999). J. Virol., 73, 4705–4712.

  • Banchereau J and Palucka AK . (2005). Nat. Rev. Immunol., 5, 296–306.

  • Barber GN . (2000). Semin. Cancer Biol., 10, 103–111.

  • Barber GN . (2004). Viral Immunol., 17, 516–527.

  • Bergman I, Whitaker-Dowling P, Gao Y, Griffin JA and Watkins SC . (2003). Virology, 316, 337–347.

  • Bergmann M, Romirer I, Sachet M, Fleischhacker R, Garcia-Sastre A, Palese P, Wolff K, Pehamberger H, Jakesz R and Muster T . (2001). Cancer Res., 61, 8188–8193.

  • Bi Z, Barna M, Komatsu T and Reiss CS . (1995). J. Virol., 69, 6466–6472.

  • Biederer C, Ries S, Brandts CH and McCormick F . (2002). J. Mol. Med., 80, 163–175.

  • Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A and McCormick F . (1996). Science, 274, 373–376.

  • Bjornsti MA and Houghton PJ . (2004). Cancer Cell, 5, 519–523.

  • Boehme KW and Compton T . (2004). J. Virol., 78, 7867–7873.

  • Carneiro FA, Bianconi ML, Weissmuller G, Stauffer F and Da Poian AT . (2002). J. Virol., 76, 3756–3764.

  • Chiocca EA . (2002). Nat. Rev. Cancer, 2, 938–950.

  • Clemens MJ . (2001). Prog. Mol. Subcell Biol., 27, 57–89.

  • Coffey MC, Strong JE, Forsyth PA and Lee PW . (1998). Science, 282, 1332–1334.

  • Connor JH and Lyles DS . (2002). J. Virol., 76, 10177–10187.

  • Connor JH and Lyles DS . (2005). J. Biol. Chem., 280, 13512–13519.

  • de Mattos C, de Mattos CC and Rupprecht CE . (2001). Rhabdoviridae: The Viruses and their Replication 4th edn. Lippincott Williams and Wilkins: New York.

    Google Scholar 

  • Desforges M, Charron J, Berard S, Beausoleil S, Stojdl DF, Despars G, Laverdiere B, Bell JC, Talbot PJ, Stanners CP and Poliquin L . (2001). Virus Res., 76, 87–102.

  • Donze O, Jagus R, Koromilas AE, Hershey JW and Sonenberg N . (1995). EMBO J., 14, 3828–3834.

  • Ebert O, Shinozaki K, Kournioti C, Park MS, Garcia-Sastre A and Woo SL . (2004). Cancer Res., 64, 3265–3270.

  • Enninga J, Levy DE, Blobel G and Fontoura BM . (2002). Science, 295, 1523–1525.

  • Faria PA, Chakraborty P, Levay A, Barber GN, Ezelle HJ, Enninga J, Arana C, van Deursen J and Fontoura BM . (2005). Mol. Cell, 17, 93–102.

  • Fernandez M, Porosnicu M, Markovic D and Barber GN . (2002). J. Virol., 76, 895–904.

  • Gomez E, Mohammad SS and Pavitt GD . (2002). EMBO J., 21, 5292–5301.

  • Hammon WM, Yohn DS, Casto BC and Atchison RW . (1963). J. Natl. Cancer Inst., 31, 329–345.

  • Hay N and Sonenberg N . (2004). Genes Dev., 18, 1926–1945.

  • Hershey JW . (1991). Annu. Rev. Biochem., 60, 717–755.

  • Hii SI, Hardy L, Crough T, Payne EJ, Grimmett K, Gill D and McMillan NA . (2004). Int. J. Cancer, 109, 329–335.

  • Holland EC, Sonenberg N, Pandolfi PP and Thomas G . (2004). Oncogene, 23, 3138–3144.

  • Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N and Taniguchi T . (2005). Nature, 434, 772–777.

  • Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM and Fisher PB . (2002). Proc. Natl. Acad. Sci. USA, 99, 637–642.

  • Kapp LD and Lorsch JR . (2004). Annu. Rev. Biochem., 73, 657–704.

  • Kim SH, Gunnery S, Choe JK and Mathews MB . (2002). Oncogene, 21, 8741–8748.

  • Kimball SR . (2001). Prog. Mol. Subcell Biol., 26, 155–184.

  • Kimball SR, Heinzinger NK, Horetsky RL and Jefferson LS . (1998). J. Biol. Chem., 273, 3039–3044.

  • Koromilas AE, Roy S, Barber GN, Katze MG and Sonenberg N . (1992). Science, 257, 1685–1689.

  • Lamberti A, Caraglia M, Longo O, Marra M, Abbruzzese A and Arcari P . (2004). Amino Acids, 26, 443–448.

  • Leegwater PA, Vermeulen G, Konst AA, Naidu S, Mulders J, Visser A, Kersbergen P, Mobach D, Fonds D, van Berkel CG, Lemmers RJ, Frants RR, Oudejans CB, Schutgens RB, Pronk JC and van der Knaap MS . (2001). Nat. Genet., 29, 383–388.

  • Lengyel P . (1993). Proc. Natl. Acad. Sci. USA, 90, 5893–5895.

  • Lodish HF and Porter M . (1980). J. Virol., 36, 719–733.

  • Malmgaard L . (2004). J. Interferon. Cytokine Res., 24, 439–454.

  • Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M and Schreiber RD . (1996). Cell, 84, 431–442.

  • Merrick WC . (2004). Gene, 332, 1–11.

  • Meurs E, Chong K, Galabru J, Thomas NS, Kerr IM, Williams BR and Hovanessian AG . (1990). Cell, 62, 379–390.

  • Meurs EF, Galabru J, Barber GN, Katze MG and Hovanessian AG . (1993). Proc. Natl. Acad. Sci. USA, 90, 232–236.

  • Muller U, Steinhoff U, Reis LF, Hemmi S, Pavlovic J, Zinkernagel RM and Aguet M . (1994). Science, 264, 1918–1921.

  • Obuchi M, Fernandez M and Barber GN . (2003). J. Virol., 77, 8843–8856.

  • Ochsenbein AF, Fehr T, Lutz C, Suter M, Brombacher F, Hengartner H and Zinkernagel RM . (1999). Science, 286, 2156–2159.

  • Pandolfi PP . (2004). Oncogene, 23, 3134–3137.

  • Pasare C and Medzhitov R . (2003). Curr. Opin. Immunol., 15, 677–682.

  • Pavitt GD, Ramaiah KV, Kimball SR and Hinnebusch AG . (1998). Genes Dev., 12, 514–526.

  • Pavitt GD, Yang W and Hinnebusch AG . (1997). Mol. Cell. Biol., 17, 1298–1313.

  • Petersen JM, Her LS, Varvel V, Lund E and Dahlberg JE . (2000). Mol. Cell. Biol., 20, 8590–8601.

  • Pitha PM . (2000). Semin. Cancer Biol., 10, 69–72.

  • Plakhov IV, Arlund EE, Aoki C and Reiss CS . (1995). Virology, 209, 257–262.

  • Porosnicu M, Mian A and Barber GN . (2003). Cancer Res., 63, 8366–8376.

  • Proud CG . (2001). Prog. Mol. Subcell Biol., 26, 95–114.

  • Richter JD and Sonenberg N . (2005). Nature, 433, 477–480.

  • Roberts A, Buonocore L, Price R, Forman J and Rose JK . (1999). J. Virol., 73, 3723–3732.

  • Roberts A, Kretzschmar E, Perkins AS, Forman J, Price R, Buonocore L, Kawaoka Y and Rose JK . (1998). J. Virol., 72, 4704–4711.

  • Ron D . (2002). J. Clin. Invest., 110, 1383–1388.

  • Rose JK and Whitt MA . (2001). Rhabdoviridae: The Viruses and their Replication 4th edn. Lippincott Williams and Wilkins: New York.

    Google Scholar 

  • Rose NF, Roberts A, Buonocore L and Rose JK . (2000). J. Virol., 74, 10903–10910.

  • Ruggero D and Pandolfi PP . (2003). Nat. Rev. Cancer, 3, 179–192.

  • Salomoni P and Pandolfi PP . (2002). Cell, 108, 165–170.

  • Schnell MJ, Buonocore L, Whitt MA and Rose JK . (1996). J. Virol., 70, 2318–2323.

  • Schnell MJ, Johnson JE, Buonocore L and Rose JK . (1997). Cell, 90, 849–857.

  • Sherr CJ . (2001). Nat. Rev. Mol. Cell Biol., 2, 731–737.

  • Stark GR, Kerr IM, Williams BR, Silverman RH and Schreiber RD . (1998). Annu. Rev. Biochem., 67, 227–264.

  • Stojdl DF, Lichty B, Knowles S, Marius R, Atkins H, Sonenberg N and Bell JC . (2000). Nat. Med., 6, 821–825.

  • Stojdl DF, Lichty BD, tenOever BR, Paterson JM, Power AT, Knowles S, Marius R, Reynard J, Poliquin L, Atkins H, Brown EG, Durbin RK, Durbin JE, Hiscott J and Bell JC . (2003). Cancer Cell, 4, 263–275.

  • Tanaka N and Taniguchi T . (2000). Semin. Cancer Biol., 10, 73–81.

  • Thomsen AR, Nansen A, Andersen C, Johansen J, Marker O and Christensen JP . (1997). Int. Immunol., 9, 1757–1766.

  • Tough DF . (2004). Leuk. Lymphoma, 45, 257–264.

  • van den Pol AN, Dalton KP and Rose JK . (2002). J. Virol., 76, 1309–1327.

  • Varghese S and Rabkin SD . (2002). Cancer Gene Ther., 9, 967–978.

  • von Kobbe C, van Deursen JM, Rodrigues JP, Sitterlin D, Bachi A, Wu X, Wilm M, Carmo-Fonseca M and Izaurralde E . (2000). Mol. Cell., 6, 1243–1252.

  • Wang S, Rosenwald IB, Hutzler MJ, Pihan GA, Savas L, Chen JJ and Woda BA . (1999). Am. J. Pathol., 155, 247–255.

  • Wang X, Paulin FE, Campbell LE, Gomez E, O’Brien K, Morrice N and Proud CG . (2001). EMBO J., 20, 4349–4359.

  • Williams DD, Price NT, Loughlin AJ and Proud CG . (2001). J. Biol. Chem., 276, 24697–24703.

  • Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S and Fujita T . (2004). Nat. Immunol., 5, 730–737.

  • Zhang K and Kaufman RJ . (2004). J. Biol. Chem., 279, 25935–25938.

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, 33136, FL, USA

    Glen N Barber

Authors
  1. Glen N Barber
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Glen N Barber.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Barber, G. VSV-tumor selective replication and protein translation. Oncogene 24, 7710–7719 (2005). https://doi.org/10.1038/sj.onc.1209042

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1209042

Keywords

This article is cited by

Search

Advanced search

Quick links