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Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S

Oncogene volume 24, pages 2756–2764 (2005)Cite this article

Abstract

The nematode Caenorhabditis elegans offers a powerful model system to study cell division control during animal development. Progress from the one-cell zygote to adult stage follows a nearly invariant pattern of divisions. This, combined with a transparent body and efficient genetics, allows for sensitive identification and quantitative analysis of cell-cycle mutants. Nearly all G1 control genes identified in C. elegans have mammalian homologs. Examples include a D-type cyclin and CDK4/6-related kinase, a member of the retinoblastoma protein family and CDK inhibitors of the Cip/Kip family. Genetic studies have placed the currently known G1 regulators into pathways similar to those in mammals. Together, this validates the use of C. elegans in identifying additional regulators of cell-cycle entry and exit. For instance, we recently found that the CDC-14 phosphatase promotes maintenance of the quiescent state. Here, we describe cell-cycle control as an integral part of C. elegans development, summarize current knowledge of G1 control genes in the worm, compare the results with those obtained in other species, and discuss the possible implications of cell-cycle studies in C. elegans for higher organisms, including humans.

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Acknowledgements

We thank our many colleagues and collaborators for generously sharing reagents and ideas, and apologize to those whose valuable work could not be cited owing to space constraints. We thank Mike Boxem, John S. Satterlee and Inge The for their suggestions and critical review of the manuscript. This work was funded by grants from the Claudia Adams Barr Program (to JK) and the National Institutes of Health (to SvdH).

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Authors and Affiliations

  1. MGH Cancer Center, Harvard Medical School, Charlestown, MA, 02129, USA

    John Koreth & Sander van den Heuvel

  2. Dana Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115, USA

    John Koreth

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  1. John Koreth
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  2. Sander van den Heuvel
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Correspondence to Sander van den Heuvel.

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Koreth, J., van den Heuvel, S. Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S. Oncogene 24, 2756–2764 (2005). https://doi.org/10.1038/sj.onc.1208607

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