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Dysregulation of apoptosis genes in hematopoietic malignancies

Oncogene volume 21, pages 3459–3474 (2002)Cite this article

Abstract

Ever since the discovery of Bcl-2 and the elucidation of its role in apoptosis, tremendous interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge emerging from apoptosis research. In this review, we summarize information about the multiple genetic lesions which have been identified in apoptosis-regulatory genes of hematopoietic and lymphoid neoplasms. Emerging data about the structural and biochemical details of apoptosis proteins and their upstream regulators have reveal novel strategies for therapeutic intervention, some of which are under interrogation in clinical trials currently.

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Acknowledgements

We thank R Cornell and A Sawyer for manuscript preparation, and gratefully acknowledge the generous support of the National Cancer Institute (NCI), American Society of Hematology, and Canadian Institute of Health Research.

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  1. The Burnham Institute, 10901 N. Torrey Pines Rd, La Jolla, 92037, California, CA, USA

    Shinichi Kitada, Irene M Pedersen, Aaron D Schimmer & John C Reed

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  1. Shinichi Kitada
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  2. Irene M Pedersen
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  3. Aaron D Schimmer
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Correspondence to John C Reed.

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Kitada, S., Pedersen, I., Schimmer, A. et al. Dysregulation of apoptosis genes in hematopoietic malignancies. Oncogene 21, 3459–3474 (2002). https://doi.org/10.1038/sj.onc.1205327

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