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A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26

Molecular Psychiatry volume 6, pages 342–349 (2001)Cite this article

Abstract

In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing of 10 cM in a series of 75 families, comprising 66 families from Germany, eight families from Israel, and one family from Italy. The families were ascertained through index cases with bipolar affective disorder. The distribution of diagnoses is as follows: 126 individuals with bipolar I disorder, 40 with bipolar II disorder, 14 with schizoaffective disorder of the bipolar type, 40 individuals with recurrent unipolar depression, 51 with a minor psychiatric diagnosis, and two individuals with a diagnosis of schizophrenia. One hundred and seventy-one individuals are unaffected. Here, we present results from chromosome 10. Linkage analyses using a total of 33 microsatellite markers with parametric and non-parametric methods provided evidence for linkage at chromosomal region 10q25–q26. The highest two-point LOD score (2.86, θ = 0.05) was obtained for D10S217 using a dominant genetic model and a broad definition of affection status. The GENEHUNTER program localized the putative susceptibility locus within a ca 15-cM interval between markers D10S1483 and D10S217 with a maximum NPL(all) score of 3.12 (P = 0.0013). Positive linkage findings that have been reported by two independent studies further support the hypothesis of a susceptibility gene for bipolar affective disorder on 10q25–q26.

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Acknowledgements

We are greatly indebted to the invaluable cooperation of the patients and their families. This study was supported by the DFG Schwerpunktprogramm ‘Genetische Faktoren bei psychiatrischen Erkrankungen’ and the Sonderforschungsbereich (SFB) 400.

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Authors and Affiliations

  1. Institute of Human Genetics, University of Bonn, Wilhelmstr 31, Bonn, D-53111, Germany

    S Cichon, G Schmidt-Wolf, J Schumacher, D J Müller, M Hürter, P Propping & M M Nöthen

  2. Department of Psychiatry, University of Bonn, Sigmund-Freud-Str 25, Bonn, D-53105, Germany

    T G Schulze, D Lichtermann, W Maier & M Rietschel

  3. Mental State Hospital Haar, Vockestr 72, Haar, D-85540, Germany

    M Albus & M Borrmann-Hassenbach

  4. Department of Psychiatry, University of Würzburg, Füchsleinstr 15, Würzburg, D-97080, Germany

    E Franzek & M Lanczik

  5. Department of Psychiatry, University of Frankfurt, Heinrich-Hoffmann-Str 10, Frankfurt/Main, D-60528, Germany

    J Fritze

  6. Department of Psychiatry, TU Dresden, Fetscherstr 74, Dresden, D-01307, Germany

    R Kreiner & B Weigelt

  7. Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Mainz, D-55131, Germany

    J Minges

  8. Department of Psychiatry, Hadassah University, Jerusalem, Israel

    B Lerer & K Kanyas

  9. Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Sigmund-Freud-Str 25, Bonn, D-53105, Germany

    G Schmidt-Wolf, K Strauch, C Windemuth, M P Baur & T F Wienker

  10. Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, Antwerp, 2610, Belgium

    M M Nöthen

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  1. S Cichon
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Cichon, S., Schmidt-Wolf, G., Schumacher, J. et al. A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25–q26. Mol Psychiatry 6, 342–349 (2001). https://doi.org/10.1038/sj.mp.4000864

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