Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

A microelectronic DNA chip detects the V617F JAK-2 mutation in myeloproliferative disorders

Leukemia volume 20, pages 1895–1897 (2006)Cite this article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. James C, Ugo V, Le Couedic JP, Staerk J, Delhommeau F, Lacout C et al. A unique clonal JAK2 mutation leading to constitutive signaling causes polycythemia vera. Nature 2005; 434: 1144–1148.

    Article  CAS  Google Scholar 

  2. Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S et al. Acquired mutation of the tyrosine kinase JAK2 in human myoloproliferative disorders. Lancet 2005; 365: 1054–1061.

    Article  CAS  Google Scholar 

  3. Kralovics R, Passamonti F, Buser AF, Tea S-S, Tiedt R, Passweg JR et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 2005; 352: 1779–1790.

    Article  CAS  Google Scholar 

  4. Tefferi A, Sirhan S, Lasho TL, Schwager SM, Li C-Y, Dingli D et al. Concomitant neutrophil JAK2 mutation screening and PRV-1 expression analysis in myeloproliferative disorders and secondary polycythemia. Br J Haematol 2005; 131: 166–171.

    Article  CAS  Google Scholar 

  5. Sattler M, Walz C, Crowley BJ, Lengfelder E, Janne PA, Rogers A et al. A sensitive high-throughput method to detect activating mutation of Jak2 in peripheral-blood samples. Blood 2006; 107: 1237–1238.

    Article  CAS  Google Scholar 

  6. Ferrari F, Foglieni B, Arosio P, Camaschella C, Daraio F, Levi S et al. Microelectronic DNA chip for hereditary hyperferritinemia cataract syndrome. A model for large-scale analysis of disorders of iron metabolism. Hum Mut 2006; 27: 201–208.

    Article  CAS  Google Scholar 

  7. Levine RL, Belisle C, Wadleigh M, Zahrieh D, Lee S, Chagnon P et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 2006; 107: 4139–4141.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Section, University of Perugia, Perugia, Italy

    M Di Ianni, L Moretti, B Del Papa, E Gaozza, A S Bell & F Falzetti

  2. Department of Internal Medicine and Public Health, University of L’Aquila, L’Aquila, Italy

    A Tabilio

Authors
  1. M Di Ianni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L Moretti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B Del Papa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E Gaozza
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A S Bell
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F Falzetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Tabilio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Tabilio.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Di Ianni, M., Moretti, L., Del Papa, B. et al. A microelectronic DNA chip detects the V617F JAK-2 mutation in myeloproliferative disorders. Leukemia 20, 1895–1897 (2006). https://doi.org/10.1038/sj.leu.2404360

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404360

This article is cited by

Search

Advanced search

Quick links