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An Atlas on Chromosomes in Hematological Malignancies. Example: 11q23 and MLL partners

Leukemia volume 15, pages 987–989 (2001)Cite this article

Genomics is a recent field of the sciences, with fast growth. For instance, a rapidly increasing number of (genetic) disorders of the cell have proved to be targets for cancer. Data are evolving permanently, and it has become a real task to make available the state of the art to the medical community. Yet, data on genomic changes in cancer have crucial importance in diagnostic ascertainment, prognostic evaluation, and treatment decisions. About 300 different haematologic malignancies can be classified according to a given chromosome aberration, often implying a given prognosis,1,2,3 and a thousand genes are more or less implicated in cancer. There is a need for databases collecting and summarising the knowledge accumulated from researchers and clinicians. We present an example of such databases, the ‘Atlas of Genetics and Cytogenetics in Oncology and Haematology’4 URL: http://www.infobiogen.fr/services/chromcancer; this is a database of free access on the Internet devoted to chromosome abnormalities in cancer, cancer-prone diseases, and genes involved in cancer. It presents information in the form of concise and updated reviews (cards). It is complementary to the Catalog of Chromosome Aberrations in Cancer.2 It is part of the genome project, and a tie in the genetics network; it is also a portfolio dedicated to chromosomes from bands to sequence. The Atlas is a peer-reviewed on-line journal and database, and, as such, it is indexed by the Current Web Contents.

The site is presented in the following way: Cards on (1) genes, (2) cytogenetic/clinical entities in hematology, (3) solid tumours, and (4) cancer-prone diseases represent the body of the Atlas. Cards on genes include data on DNA, RNA, and protein, mutations, and diseases where this gene is implicated. Cards on cytogenetic entities, on clinical entities in haematology, and cards on solid tumours include data on clinics, pathology, and prognosis, cytogenetics, genes, hybrid genes, and fusion protein. Cards on cancer-prone diseases include data on inheritance mode, phenotype, clinics, and neoplastic risk, cytogenetics, genes and proteins, mutations. Each card also includes a bibliography with hyperlinks to Medline, and hyperlinks towards other databases, which makes it easy to access a gene, its nucleotide sequence, amino-acid content and many other features. Contributions are reviewed before acceptance.

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References

  1. Mitelman F, Mertens F, Johansson . A breakpoint map of recurrent chromosomal rearrangements in human neoplasia Nat Genet 1997 15: 417–474

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  2. Mitelman F, Johansson B, Mertens F . Catalog of Chromosome Aberrations in Cancer 98 CD-ROM. John Wiley & Sons: http://www.wiley.com/products/subject/life/mitelman/

  3. http://www.infobiogen.fr/services/chromcancer/Collabo/cytoentities. html<CHROM†CLIN

  4. Huret JL, Dessen P, Bernheim A . Atlas of Genetics and Cytogenetics in Oncology and Haematology, Updated Nucleic Acids Res 2001 29: 303–304

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Acknowledgements

The Atlas of Genetics and Cytogenetics in Oncology and Haematology is funded by Ligue Nationale contre le Cancer, Comités de l’ Indre, de la Charente, et de la Vienne, and benefits from INFOBIOGEN resources.

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Authors and Affiliations

  1. Genetics, Dept Medical Information, University Hospital, Poitiers, France

    JL Huret

  2. Service de Bioinformatique CNRS/INSERM, Villejuif, France

    P Dessen

  3. Cytogénétique et Génétique Oncologiques, Villejuif, IGR PR2, France

    A Bernheim

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  1. JL Huret
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  2. P Dessen
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  3. A Bernheim
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Huret, J., Dessen, P., Bernheim, A. et al. An Atlas on Chromosomes in Hematological Malignancies. Example: 11q23 and MLL partners. Leukemia 15, 987–989 (2001). https://doi.org/10.1038/sj.leu.2402135

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