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The role of Homeobox genes in normal hematopoiesis and hematological malignancies

Leukemia volume 13, pages 1675–1690 (1999)Cite this article

Abstract

In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in addition, they are contributing to organization and regulation of hematopoiesis. Modern molecular technologies showed that deregulated expression or disruption of Hox genes can lead to altered characteristics of blood cells or disturbance of blood cell development. In this paper we review the role of HOX proteins in hematopoiesis and leukemogenesis and speculate about their possible target genes and involvement in lymphomagenesis.

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Authors and Affiliations

  1. Department of Hematology, University Hospital, Vrije Universiteit, De Boelelaan 1117, Amsterdam, 1081, HV, The Netherlands

    JW van Oostveen

  2. Department of Pathology, University Hospital, Vrije Universiteit, De Boelelaan 1117, Amsterdam, 1081, HV, The Netherlands

    JJ Bijl, FM Raaphorst, JJM Walboomers & CJLM Meijer

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  1. JW van Oostveen
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  2. JJ Bijl
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  3. FM Raaphorst
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  4. JJM Walboomers
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  5. CJLM Meijer
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van Oostveen, J., Bijl, J., Raaphorst, F. et al. The role of Homeobox genes in normal hematopoiesis and hematological malignancies. Leukemia 13, 1675–1690 (1999). https://doi.org/10.1038/sj.leu.2401562

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  • DOI: https://doi.org/10.1038/sj.leu.2401562

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