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Serum concentrations of TNF-α and soluble TNF-α receptors in obesity

International Journal of Obesity volume 24, pages 1392–1395 (2000)Cite this article

Abstract

OBJECTIVE: To study whether weight reducing treatment modulates serum concentration of TNF-α and two soluble TNF-α receptors in obese subjects.

SUBJECTS AND MEASUREMENTS: Serum concentrations of TNF-α and two soluble receptors (sTNF-R1, sTNF-R2), plasma glucose, insulin, total cholesterol, HDL-cholesterol and triglicerides were measured in 27 obese subjects (age 48±12 y, body mass index (BMI): 36±6 kg/m2) before and after 3 months weight reducing treatment consisted of a diet & 1000 kcal/day and physical exercises.

RESULTS: The mean loss of weight during 3 months' treatment was 9.3±3.3 kg. The serum concentration of TNF-α decreased after weight loss and at the same time both of the receptors (sTNF-R1,sTNF-R2) increased significantly.

CONCLUSION: The observed decrease of the serum concentration of TNF-α and the increase in both TNF soluble receptors after weight reducing treatment in obese subjects, may be a counter-regulation preventing further weight loss.

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Authors and Affiliations

  1. Department of Pathophysiology, Silesian University School of Medicine, Katowice, 40-752, Poland

    B Zahorska-Markiewicz, J Janowska, M Olszanecka-Glinianowicz & A Zurakowski

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  1. B Zahorska-Markiewicz
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  2. J Janowska
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  3. M Olszanecka-Glinianowicz
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  4. A Zurakowski
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Zahorska-Markiewicz, B., Janowska, J., Olszanecka-Glinianowicz, M. et al. Serum concentrations of TNF-α and soluble TNF-α receptors in obesity. Int J Obes 24, 1392–1395 (2000). https://doi.org/10.1038/sj.ijo.0801398

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