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W64R Mutation in β-3-adrenergic receptor gene and weight in a large population sample

International Journal of Obesity volume 22, pages 377–379 (1998)Cite this article

Abstract

We have investigated the W64R (Trp64Arg) mutation in the β-3-adrenergic receptor in 2270 healthy British males aged 50–61 y. The frequency of the rare R allele was 0.07 (95% confidence interval (CI) 0.06-0.08). The men showed an absence of association between W64R genotype and weight or height, both in the whole sample and in each quintile of the body mass index (BMI), and there was no association with tendency to gain weight. The W64R heterozygous state appears not to be a major contributing factor to obesity in the general population.

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Author notes

  1. SD O'Dell & INM Day

    Present address: Wessex Human Genetics Institute, Duthie Building (MP 808), Southampton University Hospitals NHS Trust, Tremona Road, Southampton, SO16 6YD, UK

Authors and Affiliations

  1. Division of Cardiovascular Genetics, Department of Medicine, University College London Medical School, The Rayne Institute, London, WC1E 6JJ

    SD O'Dell, MK Bolla, SE Humphries & INM Day

  2. MRC Epidemiology and Medical Care Unit, Wolfson Institute for Preventative Medicine, St Bartholomew's and The Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, London, EC1M 6BQ, UK

    GJ Miller & JA Cooper

Authors
  1. SD O'Dell
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  2. MK Bolla
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  3. GJ Miller
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  4. JA Cooper
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  5. SE Humphries
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  6. INM Day
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Correspondence to SD O'Dell.

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O'Dell, S., Bolla, M., Miller, G. et al. W64R Mutation in β-3-adrenergic receptor gene and weight in a large population sample. Int J Obes 22, 377–379 (1998). https://doi.org/10.1038/sj.ijo.0800598

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  • DOI: https://doi.org/10.1038/sj.ijo.0800598

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