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British Journal of Cancer (2006) 94, 1672-1677.
doi:10.1038/sj.bjc.6603155 Published online 16 May 2006
Securin (hPTTG1) expression is regulated by
-catenin/TCF in human colorectal carcinomaF Hlubek1, S Pfeiffer1, J Budczies2, S Spaderna3, A Jung1, T Kirchner1 and T Brabletz3
1Department of Pathology, Ludwig-Maximilians University of Munich, Thalkirchner Str. 36, 80337 Munich, Germany
2oligene GmbH, Campus Charité Mitte, Schumannstr. 20/21, 10117 Berlin, Germany
3Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany
Correspondence to: Dr F Hlubek, E-mail: Falk.Hlubek@med.uni-muenchen.de
Revised 15 March 2006; accepted 5 April 2006; published online 16 May 2006
Overexpression of the transcriptional activator
-catenin, mostly owing to loss-of-function mutations of the adenomatous polyposis coli (APC) tumour suppressor gene, is crucial for the initiation and progression of human colorectal carcinogenesis. Securin is a regulator of chromosome separation and its overexpression has been shown to be involved in different tumour-promoting processes, like transformation, hyperproliferation and angiogenesis, and correlates with tumour cell invasion. However, the molecular mechanism leading to securin overexpression in human colorectal cancer is unknown. Here we show a correlated high expression of -catenin and securin (hPTTG1) in colorectal adenomas and carcinomas and further demonstrate that securin is a target of -catenin transcriptional activation. This implies that deregulation of the -catenin/T-cell factor-signalling pathway leads to overexpression of securin in human colorectal cancer, which subsequently may contribute to tumour progression.Keywords: colorectal carcinoma;
-catenin; human pituitary tumour transforming gene; hPTTG1; Wnt-signallingback to top  |
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| Print ISSN: 0007-0920 | Online ISSN: 1532-1827 | © 2006 Cancer Research UK | ||
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