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Metabolism and proliferation share common regulatory pathways in cancer cells

Oncogene volume 29, pages 4369–4377 (2010)Cite this article

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Abstract

Cancer development involves major alterations in cells’ metabolism. Enhanced glycolysis and de novo fatty acids synthesis are indeed characteristic features of cancer. Cell proliferation and metabolism are tightly linked cellular processes. Others and we have previously shown a close relationship between metabolic responses and proliferative stimuli. In addition to trigger proliferative and survival signaling pathways, most oncoproteins also trigger metabolic changes to transform the cell. We present herein the view that participation of cell-cycle regulators and oncogenic proteins to cancer development extend beyond the control of cell proliferation, and discuss how these new functions may be implicated in metabolic alterations concomitant to the pathogenesis of human cancers.

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Acknowledgements

Members of the Fajas’ lab are acknowledged for support and discussions. This work was supported by grants from Agence Nationale pour la Recherche (ANR physio), Association pour la Recherche contre le Cancer, Institut National du Cancer (INCA) and Fondation pour la Recherche Médicale. VF was supported by a grant from the INCA.

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  1. Institut de Recherche en Cancérologie de Montpellier, Montpellier, France

    V Fritz & L Fajas

  2. INSERM, U896, Montpellier, France

    V Fritz & L Fajas

  3. Université de Montpellier1, Montpellier, France

    V Fritz & L Fajas

  4. CRLC Val d’Aurelle Paul Lamarque, IRCM, Montpellier, France

    V Fritz & L Fajas

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Fritz, V., Fajas, L. Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene 29, 4369–4377 (2010). https://doi.org/10.1038/onc.2010.182

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