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Histone deacetylases and the immunological network: implications in cancer and inflammation

Oncogene volume 29, pages 157–173 (2010)Cite this article

Abstract

The initiation, magnitude and duration of an immune response against antigens are a tightly regulated process involving a dynamic, orchestrated balance of pro- and anti-inflammatory pathways in immune cells. Such a delicate balance is critical for allowing efficient immune response against foreign antigens while preventing autoimmune attack against self-antigens. In recent years, much effort has been devoted to understanding immune evasion by cancer cells. Also, significant advances have been made in mechanistically understanding the role of pro- and anti-inflammatory cytokines in the regulation of immune responses against antigens, including those expressed by tumors. However, we still know very little about the regulation of inflammatory/anti-inflammatory genes in their natural setting, the chromatin substrate. Several mechanisms have been identified to influence chromatin flexibility and allow dynamic changes in gene expression. Among those, chromatin modifications induced by acetylation and deacetylation of histone tails have gained wide attention. In this study, we discuss the role of histone deacetylases in the transcriptional regulation of genes involved in the inflammatory response and how these enzymes coordinate the dynamic expression of these genes during an immune response. This emerging knowledge is opening new avenues to better understand epigenetic regulation of inflammatory responses and providing new molecular targets for either amplifying or ameliorating immune responses.

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Acknowledgements

The work in our laboratories was supported by grants to ES from the National Institutes of Health (NIH), the American Heart Association and the Kaul Foundation, and to EMS from the NIH.

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  1. A Villagra, E M Sotomayor and E Seto: These authors contributed equally to this study.

Authors and Affiliations

  1. Department of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL, USA

    A Villagra & E Seto

  2. Department of Immunology, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL, USA

    A Villagra & E M Sotomayor

  3. Department of Malignant Hematology, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL, USA

    A Villagra & E M Sotomayor

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  1. A Villagra
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Correspondence to A Villagra, E M Sotomayor or E Seto.

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Villagra, A., Sotomayor, E. & Seto, E. Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene 29, 157–173 (2010). https://doi.org/10.1038/onc.2009.334

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