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It's T-ALL about Notch

Oncogene volume 27, pages 5082–5091 (2008)Cite this article

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subset of ALL with poor clinical outcome compared to B-ALL. Therefore, to improve treatment, it is imperative to delineate the molecular blueprint of this disease. This review describes the central role that the Notch pathway plays in T-ALL development. We also discuss the interactions between Notch and the tumor suppressors Ikaros and p53. Loss of Ikaros, a direct repressor of Notch target genes, and suppression of p53-mediated apoptosis are essential for development of this neoplasm. In addition to the activating mutations of Notch previously described, this review will outline combinations of mutations in pathways that contribute to Notch signaling and appear to drive T-ALL development by ‘mimicking’ Notch effects on cell cycle and apoptosis.

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Acknowledgements

We thank the members of the Capobianco Laboratory for their support and critical reading of the manuscript. This work was funded by NIH Grant R01 (AJ Capobianco). RM Demarest was funded by training program in Basic Cancer Research from Wistar Institute (T32 CA09171).

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  1. R M Demarest and F Ratti: These authors contributed equally to this work.

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  1. Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA

    R M Demarest, F Ratti & A J Capobianco

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Demarest, R., Ratti, F. & Capobianco, A. It's T-ALL about Notch. Oncogene 27, 5082–5091 (2008). https://doi.org/10.1038/onc.2008.222

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