Nature Structural & Molecular Biology11, 394 - 403 (2004)
Published online: 27 April 2004; | doi:10.1038/nsmb763
Structure and mechanism of the RNA polymerase II transcription machinery
Steven Hahn
Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, 1100 Fairview Ave N., A1-162, Seattle, Washington 98109, USA.
Correspondence should be addressed to Steven Hahn shahn@fhcrc.org
Advances in structure determination of the bacterial and eukaryotic transcription machinery have led to a marked increase in the understanding of the mechanism of transcription. Models for the specific assembly of the RNA polymerase II transcription machinery at a promoter, conformational changes that occur during initiation of transcription, and the mechanism of initiation are discussed in light of recent developments.
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