The DEAD-box ATPase Ded1 unwinds duplex RNA with a single-stranded overhang; however, Ded1 requires the overhang not for translocation but rather for loading onto the duplex. This surprising finding expands the mechanistic repertoire for the ubiquitous DExD/H-box family.
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Mayas, R., Staley, J. DEAD on. Nat Struct Mol Biol 13, 954–955 (2006). https://doi.org/10.1038/nsmb1106-954
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DOI: https://doi.org/10.1038/nsmb1106-954