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Nature Structural & Molecular Biology 14, 887 - 888 (2007)
doi:10.1038/nsmb1007-887
Sensing of DNA damage by XPC/Rad4: one protein for many lesions
Kaoru Sugasawa1 & Fumio Hanaoka2
- Kaoru Sugasawa is at the Biosignal Research Center, Organization of Advanced Science and Technology, Kobe University, Nada-ku, Kobe 657-8501, Japan. e-mail: ksugasawa@garnet.kobe-u.ac.jp
- Fumio Hanaoka is at the Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan. e-mail: fhanaoka@fbs.osaka-u.ac.jp
Abstract
Through its crucial role in DNA damage recognition and initiation of nucleotide excision repair in mammals, XPC protein represents a first line of defense against carcinogenesis. The recent elucidation of the molecular structure of the yeast XPC homolog Rad4 provides new insights into how eukaryotic cells recognize structurally diverse DNA lesions.
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