Nature Structural & Molecular Biology
- 13, 754 - 755 (2006)
doi:10.1038/nsmb0906-754
L(ou)sy miRNA targets?Nikolaus Rajewsky
The author is at the Max Delbrück Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, Berlin-Buch, 13092 Berlin, Germany. rajewsky@mdc-berlin.de
MicroRNAs (miRNAs) are noncoding small RNAs thought to post-transcriptionally regulate many metazoan genes by binding to partially complementary sites in target messenger RNAs. In this issue, Didiano and Hobert examine known and predicted targets of the nematode lsy-6 miRNA, question the general validity of previously proposed rules about miRNA-target interactions and suggest that many functional miRNA targets might be context dependent, as seen in metazoan gene regulation by transcription factors.
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