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Think you know how miRNAs work? Think again.

Nature Structural & Molecular Biology volume 15, pages 334–336 (2008)Cite this article

Two proposed mechanisms for how microRNAs (miRNAs) and their associated Argonaute proteins inhibit translation in mammals do not seem to operate in Drosophila melanogaster cells, suggesting that insights into important miRNA functions remain elusive. However, the interaction between Argonaute and the P-body factor GW182 may help in elucidating the biochemical basis of translational control by miRNAs.

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Figure 1: miRNA-Argonaute–mediated mRNA silencing remains controversial.

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Authors and Affiliations

  1. Joel D. Richter is at the Program in Molecular Medicine, University of Massachusetts Medical School, Biotech 2, Suite 204, 373 Plantation Street, Worcester, Massachusetts 01605, USA. joel.richter@umassmed.edu,

    Joel D Richter

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  1. Joel D Richter
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Richter, J. Think you know how miRNAs work? Think again.. Nat Struct Mol Biol 15, 334–336 (2008). https://doi.org/10.1038/nsmb0408-334

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