News and Views
Nature Structural & Molecular Biology 14, 252 - 254 (2007)
doi:10.1038/nsmb0407-252
The expanding world of histone lysine demethylases
Eric Metzger1 & Roland Schüle1
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Eric Metzger and Roland Schüle are at the Universitäts-Frauenklinik und Zentrum für Klinische Forschung, Klinikum der Universität Freiburg, Breisacherstrasse 66, 79106 Freiburg, Germany.
e-mail: roland.schuele@uniklinik-freiburg.de
Abstract
Sparked by the discovery of LSD1, the first bona fide histone lysine demethylase, a burst of research has opened a new era in understanding how chromatin is regulated, including the identification of the JmjC domain–containing histone demethylases. Now, several independent studies provide evidence that yeast Yjr119Cp, human JARID1 and Drosophila Lid, all members of the JmjC family, demethylate histone H3 trimethyl-Lys4, a mark of transcriptionally active chromatin.
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