Structural genomics efforts are already producing a quarter of all 'new' macromolecular structures (<30% sequence identity to previously solved structures) and are stimulating development of systematic and automated approaches to structure determination. The thousands of new structures likely to be determined and the technologies and infrastructure likely to be developed over the next decade will benefit all biologists.
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Double blind microarray-based polysaccharide profiling enables parallel identification of uncharacterized polysaccharides and carbohydrate-binding proteins with unknown specificities
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References
Stevens, C., Yokoyama, S. & Wilson, I.A. Science 294, 89–92 (2001).
Burley, S.K. Nat. Struct. Biol. 7, 932–934 (2000).
Vitkup, D., Melamud, E., Moult, J. & Sander, C. Nat. Struct. Biol. 8, 559–566 (2001).
Terwilliger, T.C. et al. Protein Sci. 9, 1851–1856 (1998).
Harrison, S.C. Nat. Struct. Mol. Biol 11, 13–15 (2004).
Berman, H.M. et al. Nucleic Acids Res. 28, 235–242 (2000).
Zarembinski, T.I. et al. Proteins 50, 177–183 (2002).
Sutton, G. et al. Structure 12, 341–353 (2004).
Goulding, C.W. et al. Curr. Drug Targets Infect. Disord. 2, 121–141 (2002).
Zhang, C. & Kim, S.H. Curr. Opin. Chem. Biol. 7, 28–32 (2003).
Lim, K. et al. Prot. Struct. Funct. Genet. 45, 397–407 (2001).
Pieper, U. et al. Nucleic Acids. Res. 30, 255–259 (2002).
Goh, C.S. et al. J. Mol. Biol. 336, 115–130 (2004).
Christendat, D. et al. Nat. Struct. Biol. 7, 903–909 (2000).
Yokoyama, S. Curr. Opin. Chem. Biol. 7, 39–43 (2003).
Hosfield, D. et al. J. Struct. Biol. 142, 207–217 (2003).
Hansen, C.L., Skordalakes, E., Berger, J.M. & Quake, S.R. Proc. Natl. Acad. Sci. USA 99, 16531–16536 (2002).
Abola, E., Kuhn, P., Earnest, T. & Stevens, R.C. Nat. Struct. Biol. 7, 973–977 (2000).
Lamzin, V.S. & Perrakis, A.R. Nat. Struct. Biol. 7, 978–981 (2000).
Montelione, G.T., Zheng, D., Huang, Y.J., Gunsalus, K.C. & Szyperski, T. Nat. Struct. Biol. 7, 982–985 (2000).
Pedelacq, J.D. et al. Nat. Biotechnol. 20, 927–932 (2002).
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Terwilliger, T. Structures and technology for biologists. Nat Struct Mol Biol 11, 296–297 (2004). https://doi.org/10.1038/nsmb0404-296
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DOI: https://doi.org/10.1038/nsmb0404-296
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