News and Views
Nature Structural & Molecular Biology 14, 5 - 7 (2007)
doi:10.1038/nsmb0107-5
Wrong PH for RNA degradation
Elmar Wahle1
- Elmar Wahle is in the Institut of Biochemistry and Biotechnology, University of Halle, Kurt-Mothes-Str. 3, 06120 Halle, Germany. e-mail: ewahle@biochemtech.uni-halle.de
Abstract
The exosome, the major eukaryotic 3' exoribonuclease acting in processing or degradation of a wide variety of RNA substrates, contains six subunits with predicted phosphorolytic activity and a single hydrolytic subunit. Recent data suggest that the phosphorolytic subunits of the yeast enzyme are catalytically inactive, and the hydrolytic subunit is solely responsible for the activity of the core exosome.
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