The author is at the University of Texas at Austin, Austin, Texas 78712-0165, USA. tesmer@mail.utexas.edu
In mammals, a soluble bicarbonate-regulated adenylyl cyclase is required for sperm fertility. Crystal structures of a cyanobacterial cousin provide new insights into the molecular mechanisms of activation and catalysis in soluble adenylyl cyclase and other class III nucleotidyl cyclases.
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