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The fusion pores of Ca2+-triggered exocytosis

Nature Structural & Molecular Biology volume 15, pages 684–689 (2008)Cite this article

Abstract

The aqueous compartment inside a vesicle makes its first connection with the extracellular fluid through an intermediate structure termed the exocytotic fusion pore. Progress in exocytosis can be measured in terms of the formation and growth of the fusion pore. The fusion pore has become a major focus of research in exocytosis; sensitive biophysical measurements have provided various glimpses of what it looks like and how it behaves. Some of the principal questions about the molecular mechanism of exocytosis can be cast explicitly in terms of properties and transitions of fusion pores. This Review will present current knowledge about fusion pores in Ca2+-triggered exocytosis, highlight recent advances and relate questions about fusion pores to broader issues concerning how cells regulate exocytosis and how nerve terminals release neurotransmitter.

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Figure 1: Two models of membrane fusion.
Figure 2: A model of the fusion pore formed by the membrane anchors of syntaxin48.

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Acknowledgements

This work was supported by US National Institutes of Health grants to M.B.J. (NS30016 and NS44057) and by US National Institutes of Health (National Institute of General Medical Sciences GM56827 and National Institute of Mental Health MH61876) and American Heart Association (0440168N) grants to E.R.C. E.R.C. is supported by the Howard Hughes Medical Institute.

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  1. Department of Physiology, SMI 127, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, 53706, Wisconsin, USA

    Meyer B Jackson & Edwin R Chapman

  2. Howard Hughes Medical Institute, SMI 127, University of Wisconsin School of Medicine and Public Health, 1300 University Avenue, Madison, 53706, Wisconsin, USA

    Edwin R Chapman

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Jackson, M., Chapman, E. The fusion pores of Ca2+-triggered exocytosis. Nat Struct Mol Biol 15, 684–689 (2008). https://doi.org/10.1038/nsmb.1449

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