A GTPase gate for protein import into chloroplasts
Felix Kessler1
& Danny J. Schnell2
1
Felix Kessler is in the Institute of Plant Sciences, Plant Physiology and Biochemistry Group, ETH Zürich Universitätstrasse 2, 8092 Zürich, Switzerland.
2
Danny J. Schnell is in the Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Protein import into chloroplasts is regulated by the binding and hydrolysis of GTP at two homologous GTPases, Toc34 and Toc159. The crystal structure of the Toc34 GTP-binding domain suggests that GTP-regulated dimerization of the Toc GTPase domains controls the targeting and translocation of preproteins at the chloroplast envelope.
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