Treatment paradigms for advanced renal cell carcinoma (RCC) continue to be challenged and refined. Recent studies in metastatic RCC have demonstrated the efficacy of first-line cabozantinib and the safety and efficacy of dual checkpoint blockade; in the adjuvant setting, pazopanib failed to improve progression-free survival in high-risk localized RCC compared with placebo.
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Ball, M., Srinivasan, R. Challenging and refining treatment paradigms. Nat Rev Urol 15, 77–78 (2018). https://doi.org/10.1038/nrurol.2017.220
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DOI: https://doi.org/10.1038/nrurol.2017.220
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