The link between exposure to exogenous estrogen and the incidence of systemic lupus erythematosus is controversial, but new data suggest that the use of combined oral contraceptives could increase the risk of developing the disease.
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References
Mok, C. C. & Lau, C. S. Pathogenesis of systemic lupus erythematosus. J. Clin. Pathol. 56, 481–490 (2003).
Bernier, M. O., Mikaeloff, Y., Hudson, M. & Suissa, S. Combined oral contraceptive use and the risk of systemic lupus erythematosus. Arthritis Rheum. 61, 476–481 (2009).
Sanchez-Guerrero, J., Karlson, E. W., Liang, M. H., Hunter, D. J., Speizer, F. E. & Colditz, G. A. Past use of oral contraceptives and the risk of developing systemic lupus erythematosus. Arthritis Rheum. 40, 804–808 (1997).
Costenbader, K. H., Feskanich, D., Stampfer, M. J. & Karlson, E. W. Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum. 56, 1251–1262 (2007).
Kanda, N., Tsuchida, T. & Tamaki, K. Estrogen enhancement of anti-double-stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum. 42, 328–337 (1999).
Guballa, N., Sammaritano, L., Schwartzman, S., Buyon, J. & Lockshin, M. D. Ovulation induction and in vitro fertilization in systemic lupus erythematosus and antiphospholipid syndrome. Arthritis Rheum. 43, 550–556 (2000).
Buyon, J. P. et al. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann. Intern. Med. 142, 953–962 (2005).
Petri, M. et al. Combined oral contraceptives in women with systemic lupus erythematosus. N. Engl. J. Med. 353, 2550–2558 (2005).
Sánchez-Guerrero, J. et al. A trial of contraceptive methods in women with systemic lupus erythematosus. N. Engl. J. Med. 353, 2539–2549 (2005).
Lee, Y. J. et al. Association of the oestrogen receptor alpha gene polymorphisms with disease onset in systemic lupus erythematosus. Ann. Rheum. Dis. 63, 1244–1249 (2004).
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Mok, C. Is combined oral contraceptive use linked to SLE incidence?. Nat Rev Rheumatol 5, 360–361 (2009). https://doi.org/10.1038/nrrheum.2009.118
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DOI: https://doi.org/10.1038/nrrheum.2009.118
