A large study corroborates the link between depression and increased risk of subsequent Parkinson disease (PD), but whether depression is a risk factor for or a prodromal symptom of PD remains a conundrum. Consideration of nonbiological risk factors and disorders associated with depression aside from PD could elucidate this complex relationship.
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Leentjens, A. Depression—risk factor or early symptom in Parkinson disease?. Nat Rev Neurol 11, 432–433 (2015). https://doi.org/10.1038/nrneurol.2015.126
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DOI: https://doi.org/10.1038/nrneurol.2015.126
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