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Neurodegenerative disease

Cortical atrophy in syndromes of progressive aphasia

Nature Reviews Neurology volume 5, pages 471–473 (2009)Cite this article

Frontotemporal lobar degeneration often presents with distinct language impairments that are associated with different distributions of cortical atrophy. Two studies have now demonstrated that these clinical syndromes are associated with highly characteristic patterns of cortical thinning. Specific cortical atrophy profiles do not, however, seem to reliably predict histologically distinct frontotemporal lobar degeneration variants.

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Figure 1: T2-weighted MRI in a patient with semantic dementia.

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  1. R. J. S. Wise, Division of Neuroscience and Mental Health and MRC Clinical Sciences Centre, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK richard.wise@csc.mrc.ac.uk

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  1. Division of Neuroscience and Mental Health and MRC Clinical Sciences Centre, Imperial College, London, UK

    Richard J. S. Wise

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  1. Richard J. S. Wise
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Wise, R. Cortical atrophy in syndromes of progressive aphasia. Nat Rev Neurol 5, 471–473 (2009). https://doi.org/10.1038/nrneurol.2009.133

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