Key Points
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Humans and some other animals use their two eyes in coordination to support binocular depth perception. The left and right eyes obtain images of the visual scene from slightly different viewpoints, leading to small differences between the left and right images called binocular disparities.
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Measurement of the tuning functions of neurons in the visual cortex for disparity gives important information about how the visual stimulus influences the firing of neurons but does little to reveal the roles of different neurons in binocular depth perception.
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Known features of binocular stereoscopic depth perception can be used to set up tests of the role of individual neurons and individual cortical areas.
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One early hypothesis was that the dorsal visual cortical pathways are pre-eminently responsible for binocular depth perception. Other views have assigned different roles to the dorsal and ventral streams.
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Neurons outside the primary visual cortex (V1) respond consistently to relative disparity. Neurons in both dorsal and ventral extrastriate visual areas respond to relative disparity.
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It is proposed that dorsal areas are predominantly involved in processing extended visual surfaces and resolving depth structure during self-movement, whereas ventral visual areas process relative disparity to support the analysis of the three-dimensional shape of objects.
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Binocular anticorrelation can be used to map the role of different sites in the visual cortex in the generation of binocular depth perception.
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Dorsal visual areas appear to use a computational strategy based on a simple algorithm that approximately measures the cross-correlation between image regions on the left and right eyes. Ventral visual areas appear to use a more sophisticated algorithm that makes point-for-point matches between specific features on the left and right retinas.
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Binocular depth perception has been recently studied at the neuronal level using the measurement of choice probabilities and the application of electrical microstimulation within selected parts of the visual cortex.
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The identification of a significant role for the extrastriate visual cortex in the generation of binocular depth perception leads to a broadened interest in the roles of these areas in explaining some phenomena associated with the human clinical condition of amblyopia.
Abstract
Our ability to coordinate the use of our left and right eyes and to make use of subtle differences between the images received by each eye allows us to perceive stereoscopic depth, which is important for the visual perception of three-dimensional space. Binocular neurons in the visual cortex combine signals from the left and right eyes. Probing the roles of binocular neurons in different perceptual tasks has advanced our understanding of the stages within the visual cortex that lead to binocular depth perception.
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References
Cumming, B. G. & DeAngelis, G. C. The physiology of stereopsis. Ann. Rev. Neurosci. 24, 203–238 (2001). A core review article that comprehensively and critically summarises the field.
Hubel, D. H. & Livingstone, M. S. Segregation of form, color, and stereopsis in primate area-18. J. Neurosci. 7, 3378–3415 (1987).
Hubel, D. H. & Wiesel, T. N. Cells sensitive to binocular depth in area-18 of macaque monkey cortex. Nature 225, 41–42 (1970).
Poggio, G. F. & Poggio, T. The analysis of stereopsis. Ann. Rev. Neurosci. 7, 379–412 (1984).
Poggio, G. F. & Talbot, W. H. Mechanisms of static and dynamic stereopsis in foveal cortex of the rhesus-monkey. J. Physiol. 315, 469–492 (1981).
Merigan, W. H., Katz, L. M. & Maunsell, J. H. R. The effects of parvocellular lateral geniculate lesions on the acuity and contrast sensitivity of macaque monkeys. J. Neurosci. 11, 994–1001 (1991).
Merigan, W. H. & Maunsell, J. H. R. How parallel are the primate visual pathways. Ann. Rev. Neurosci. 16, 369–402 (1993).
Barberini, C. L., Cohen, M. R., Wandell, B. A. & Newsome, W. T. Cone signal interactions in direction-selective neurons in the middle temporal visual area (MT). J. Vis. 5, 603–621 (2005).
Callaway, E. M. in Cortical Function: A View From the Thalamus (eds Casagrande, V. A., Guillery, R. W. & Sherman, S. M.) 59–64 (Elsevier, Amsterdam, 2005).
Nassi, J. J., Lyon, D. C. & Callaway, E. M. The parvocellular LGN provides a robust disynaptic input to the visual motion area MT. Neuron 50, 319–327 (2006).
Yoshioka, T., Levitt, J. B. & Lund, J. S. Independence and merger of thalamocortical channels within macaque monkey primary visual cortex: anatomy of interlaminar projections. Vis. Neurosci. 11, 467–489 (1994).
Livingstone, M. S. & Hubel, D. H. Psychophysical evidence for separate channels for the perception of form, color, movement, and depth. J. Neurosci. 7, 3416–3468 (1987).
Tyler, C. W. A stereoscopic view of visual processing streams. Vision Res. 30, 1877–1895 (1990).
Schiller, P. H. The effects of V4 and middle temporal (MT) area lesions on visual performance in the rhesus-monkey. Vis. Neurosci. 10, 717–746 (1993).
Prince, S. J. D., Cumming, B. G. & Parker, A. J. Range and mechanism of encoding of horizontal disparity in macaque V1. J. Neurophysiol. 87, 209–221 (2002).
Tanabe, S., Doi, T., Umeda, K. & Fujita, I. Disparity-tuning characteristics of neuronal responses to dynamic random-dot stereograms in macaque visual area V4. J. Neurophysiol. 94, 2683–2699 (2005).
Tanabe, S., Umeda, K. & Fujita, I. Rejection of false matches for binocular correspondence in macaque visual cortical area V4. J. Neurosci. 24, 8170–8180 (2004).
DeAngelis, G. C. & Uka, T. Coding of horizontal disparity and velocity by MT neurons in the alert macaque. J. Neurophysiol. 89, 1094–1111 (2003).
Peterhans, E. & Von Der Heydt, R. Functional-organization of area V2 in the alert macaque. Eur. J. Neurosci. 5, 509–524 (1993).
Ts'o, D. Y., Roe, A. W. & Gilbert, C. D. A hierarchy of the functional organization for color, form and disparity in primate visual area V2. Vision Res. 41, 1333–1349 (2001).
Backus, B. T., Fleet, D. J., Parker, A. J. & Heeger, D. J. Human cortical activity correlates with stereoscopic depth perception. J. Neurophysiol. 86, 2054–2068 (2001).
Tsao, D. Y. et al. Stereopsis activates V3A and caudal intraparietal areas in macaques and humans. Neuron 39, 555–568 (2003).
Cumming, B. G. & Parker, A. J. Binocular neurons in V1 of awake monkeys are selective for absolute, not relative, disparity. J. Neurosci. 19, 5602–5618 (1999). Establishes that V1 neurons code absolute disparity and identified the need to search elsewhere for neurons that code relative disparity.
Rashbass, C. & Westheimer, G. Independence of conjugate and disjunctive eye movements. J. Physiol. 159, 361–364 (1961).
Westheimer, G. Co-operative neural processes involved in stereoscopic acuity. Exp. Brain Res. 36, 585–597 (1979).
Regan, D., Erkelens, C. J. & Collewijn, H. Necessary conditions for the perception of motion in depth. Invest. Ophthalmol. Vis. Sci. 27, 584–597 (1986).
Erkelens, C. J. & Collewijn, H. Stereopsis, vergence and motion perception during dichoptic vision of moving random-dot stereograms. Experientia 40, 1300–1301 (1984).
Erkelens, C. J. & Collewijn, H. Eye-movements and stereopsis during dichoptic viewing of moving random-dot stereograms. Vision Res. 25, 1689–1700 (1985).
Erkelens, C. J. & Collewijn, H. Motion perception during dichoptic viewing of moving random-dot stereograms. Vision Res. 25, 583–588 (1985).
Erkelens, C. J. & Collewijn, H. Eye-movements in relation to loss and regaining of fusion of disjunctively moving random-dot stereograms. Hum. Neurobiol. 4, 181–188 (1985).
Thomas, O. M., Cumming, B. G. & Parker, A. J. A specialization for relative disparity in V2. Nature Neurosci. 5, 472–478 (2002). Discovers sensitivity for relative disparity in V2, and proposes a model for the transformation from absolute to relative disparity.
Bredfeldt, C. E. & Cumming, B. G. A simple account of cyclopean edge responses in macaque V2. J. Neurosci. 26, 7581–7596 (2006).
Zhou, H., Friedman, H. S. & von der Heydt, R. Coding of border ownership in monkey visual cortex. J. Neurosci. 20, 6594–6611 (2000).
von der Heydt, R., Zhou, H. & Friedman, H. S. Representation of stereoscopic edges in monkey visual cortex. Vision Res. 40, 1955–1967 (2000).
Cowey, A. & Wilkinson, F. The role of the corpus-callosum and extra striate visual areas in stereoacuity in macaque monkeys. Neuropsychologia 29, 465–479 (1991).
Janssen, P., Vogels, R. & Orban, G. A. Three-dimensional shape coding in inferior temporal cortex. Neuron 27, 385–397 (2000). Breaks new ground by identifying a region of inferior temporal cortex responsible for the analysis of three-dimensional shape from stereoscopic cues.
Neri, P., Bridge, H. & Heeger, D. J. Stereoscopic processing of absolute and relative disparity in human visual cortex. J. Neurophysiol. 92, 1880–1891 (2004). This ingenious paper made a clear quantitative justification for a division of stereoscopic depth functions between the dorsal and ventral streams on the basis of human fMRI results.
Umeda, K., Tanabe, S. & Fujita, I. Relative-disparity-based coding of stereoscopic depth in V4. Soc. Neurosci. Abstr. 865.8 (2004).
Nguyenkim, J. D. & DeAngelis, G. C. Disparity-based coding of three-dimensional surface orientation by macaque middle temporal neurons. J. Neurosci. 23, 7117–7128 (2003).
Uka, T. & DeAngelis, G. C. Linking neural representation to function in stereoscopic depth perception: roles of the middle temporal area in coarse versus fine disparity discrimination. J. Neurosci. 26, 6791–6802 (2006). A careful and incisive analysis of the role of single neurons in stereo depth perception that demonstrates the task-specific role of cortical area V5/MT.
Bradley, D. C., Qian, N. & Andersen, R. A. Integration of motion and stereopsis in middle temporal cortical area of macaques. Nature 373, 609–611 (1995).
Bradley, D. C., Chang, G. C. & Andersen, R. A. Encoding of three-dimensional structure-from-motion by primate area MT neurons. Nature 392, 714–717 (1998).
Dodd, J. V., Krug, K., Cumming, B. G. & Parker, A. J. Perceptually bistable three-dimensional figures evoke high choice probabilities in cortical area. J. Neurosci. 21, 4809–4821 (2001).
Parker, A. J., Krug, K. & Cumming, B. G. Neuronal activity and its links with the perception of multi-stable figures. Philos. Trans. R. Soc. Lond. B Biol. Sci. 357, 1053–1062 (2002).
Prince, S. J. D., Pointon, A. D., Cumming, B. G. & Parker, A. J. The precision of single neuron responses in cortical area V1 during stereoscopic depth judgments. J. Neurosci. 20, 3387–3400 (2000).
Read, J. C. & Eagle, R. A. Reversed stereo and motion direction with anti-correlated stimuli. Vision Res. 40, 3345–3358 (2000).
Julesz, B. Foundations of Cyclopean Perception (Univ. Chicago Press, Chicago, 1971).
Cumming, B. G., Shapiro, S. E. & Parker, A. J. Disparity detection in anticorrelated stereograms. Perception 27, 1367–1377 (1998).
Cogan, A. I., Kontsevich, L. L., Lomakin, A. J., Halpern, D. L. & Blake, R. Binocular disparity processing with opposite-contrast stimuli. Perception 24, 33–47 (1995).
Cogan, A. I., Lomakin, A. J. & Rossi, A. F. Depth in anticorrelated stereograms — effects of spatial density and interocular delay. Vision Res. 33, 1959–1975 (1993).
Cumming, B. G. & Parker, A. J. Responses of primary visual cortical neurons to binocular disparity without depth perception. Nature 389, 280–283 (1997). Demonstrates that disparity-selective V1 neurons respond systematically to the binocular disparity of anticorrelated random-dot stereograms, despite the fact that viewing the same visual patterns does not generate the perception of stereoscopic depth.
Takemura, A., Inoue, Y., Kawano, K., Quaia, C. & Miles, F. A. Single-unit activity in cortical area MST associated with disparity-vergence eye movements: evidence for population coding. J. Neurophysiol. 85, 2245–2266 (2001). An elegant analysis that demonstrates that the firing within the neuronal population of MST is sufficient to account for the vergence eye movement responses to binocularly correlated and anticorrelated visual patterns.
Krug, K., Cumming, B. G. & Parker, A. J. Comparing perceptual signals of single V5/MT neurons in two binocular depth tasks. J. Neurophysiol. 92, 1586–1596 (2004).
Neri, P., Parker, A. J. & Blakemore, C. Probing the human stereoscopic system with reverse correlation. Nature 401, 695–698 (1999).
Fujita, I., Yasuoka, S. & Tanabe, S. Dissociation of stereoscopic depth judgment from perception of a plane-in-depth: implication for neural mechanism of stereopsis. Soc. Neurosci. Abstr. 583.1 (2005).
Doi, T., Tanabe, S. & Fujita, I. Computations underlying fine and coarse depth discrimination in human stereopsis. Soc. Neurosci. Abstr. 801.5 (2006).
Masson, G. S., Busettini, C. & Miles, F. A. Vergence eye movements in response to binocular disparity without depth perception. Nature 389, 283–286 (1997).
Ohzawa, I., DeAngelis, G. C. & Freeman, R. D. Stereoscopic depth discrimination in the visual cortex: neurons ideally suited as disparity detectors. Science 249, 1037–1041 (1990). A highly influential and successful model of the responses of disparity-selective neurons in the primary visual cortex.
Read, J. C. A., Parker, A. J. & Cumming, B. G. A simple model accounts for the response of disparity-tuned V1 neurons to anticorrelated images. Vis. Neurosci. 19, 735–753 (2002).
Read, J. C. A. & Cumming, B. G. Testing quantitative models of binocular disparity selectivity in primary visual cortex. J. Neurophysiol. 90, 2795–2817 (2003).
Allouni, A. K., Thomas, O. M., Solomon, S. G., Krug, K. & Parker, A. J. Local and global binocular matching in V2 of the awake macaque. Soc. Neurosci. Abstr. 510.8 (2005).
Janssen, P., Vogels, R., Liu, Y. & Orban, G. A. At least at the level of inferior temporal cortex, the stereo correspondence problem is solved. Neuron 37, 693–701 (2003). An important finding that establishes one cortical site where the response to binocular anticorrelation is eliminated.
Akao, T., Mustari, M. J., Fukushima, J., Kurkin, S. & Fukushima, K. Discharge characteristics of pursuit neurons in MST during vergence eye movements. J. Neurophysiol. 93, 2415–2434 (2005).
Goodale, M. A. & Milner, A. D. Separate visual pathways for perception and action. Trends Neurosci. 15, 20–25 (1992).
Mitchison, G. Planarity and segmentation in stereo matching. Perception 17, 753–782 (1987).
Cumming, B. G. & Parker, A. J. Local disparity not perceived depth is signaled by binocular neurons in cortical area V1 of the macaque. J. Neurosci. 20, 4758–4767 (2000).
Bakin, J. S., Nakayama, K. & Gilbert, C. D. Visual responses in monkey areas V1 and V2 to three-dimensional surface configurations. J. Neurosci. 20, 8188–8198 (2000).
Orban, G. A., Janssen, P. & Vogels, R. Extracting 3D structure from disparity. Trends Neurosci. 29, 466–473 (2006).
Upadhyay, U. D., Page, W. K. & Duffy, C. J. MST responses to pursuit across optic flow with motion parallax. J. Neurophysiol. 84, 818–826 (2000).
Roy, J. P. & Wurtz, R. H. The role of disparity-sensitive cortical-neurons in signaling the direction of self-motion. Nature 348, 160–162 (1990).
Roy, J. P., Komatsu, H. & Wurtz, R. H. Disparity sensitivity of neurons in monkey extrastriate area MST. J. Neurosci. 12, 2478–2492 (1992).
Uka, T., Tanabe, S., Watanabe, M. & Fujita, I. Neural correlates of fine depth discrimination in monkey inferior temporal cortex. J. Neurosci. 25, 10796–10802 (2005).
Janssen, P., Vogels, R., Liu, Y. & Orban, G. A. Macaque inferior temporal neurons are selective for three-dimensional boundaries and surfaces. J. Neurosci. 21, 9419–9429 (2001).
Tsutsui, K. I., Jiang, M., Yara, K., Sakata, H. & Taira, M. Integration of perspective and disparity cues in surface- orientation-selective neurons of area CIP. J. Neurophysiol. 86, 2856–2867 (2001).
Tanaka, H., Uka, T., Yoshiyama, K., Kato, M. & Fujita, I. Processing of shape defined by disparity in monkey inferior temporal cortex. J. Neurophysiol. 85, 735–744 (2001).
Liu, Y., Vogels, R. & Orban, G. A. Convergence of depth from texture and depth from disparity in macaque inferior temporal cortex. J. Neurosci. 24, 3795–3800 (2004).
Pouget, A., Dayan, P. & Zemel, R. S. Inference and computation with population codes. Ann. Rev. Neurosci. 26, 381–410 (2003).
Pouget, A., Deneve, S. & Duhamel, J. R. A computational perspective on the neural basis of multisensory spatial representations. Nature Rev. Neurosci. 3, 741–747 (2002).
Deneve, S., Latham, P. E. & Pouget, A. Reading population codes: a neural implementation of ideal observers. Nature Neurosci. 2, 740–745 (1999).
Nienborg, H. & Cumming, B. G. Macaque V2 neurons, but not V1 neurons, show choice-related activity. J. Neurosci. 26, 9567–9578 (2006). A meticulously conducted study that demonstrates a significant involvement of single V2 neurons in judgements about binocular depth.
Uka, T. & DeAngelis, G. C. Contribution of area MT to stereoscopic depth perception: choice-related response modulations reflect task strategy. Neuron 42, 297–310 (2004).
Parker, A. J. & Newsome, W. T. Sense and the single neuron: probing the physiology of perception. Ann. Rev. Neurosci. 21, 227–277 (1998).
Salzman, C. D., Britten, K. H. & Newsome, W. T. Cortical microstimulation influences perceptual judgments of motion direction. Nature 346, 174–177 (1990).
DeAngelis, G. C., Cumming, B. G. & Newsome, W. T. Cortical area MT and the perception of stereoscopic depth. Nature 394, 677–680 (1998).
Krug, K., Cumming, B. G. & Parker, A. J. Microstimulation alters the perceptual appearance of a rotating cylinder in the awake macaque. Soc. Neurosci. Abstr. 621.2 (2005).
Grunewald, A., Bradley, D. C. & Andersen, R. A. Neural correlates of structure-from-motion perception in macaque V1 and MT. J. Neurosci. 22, 6195–6207 (2002).
Hegde, J. & Van Essen, D. C. Stimulus dependence of disparity coding in primate visual area V4. J. Neurophysiol. 93, 620–626 (2005).
Sakata, H., Taira, M., Kusunoki, M., Murata, A. & Tanaka, Y. The TINS lecture. The parietal association cortex in depth perception and visual control of hand action. Trends Neurosci. 20, 350–357 (1997).
Galletti, C., Fattori, P., Gamberini, M. & Kutz, D. F. The cortical visual area V6: brain location and visual topography. Eur. J. Neurosci. 11, 3922–3936 (1999).
Galletti, C., Fattori, P., Kutz, D. F. & Gamberini, M. Brain location and visual topography of cortical area V6A in the macaque monkey. Eur. J. Neurosci. 11, 575–582 (1999).
Shipp, S., Blanton, M. & Zeki, S. A visuo-somatomotor pathway through superior parietal cortex in the macaque monkey: cortical connections of areas V6 and V6A. Eur. J. Neurosci. 10, 3171–3193 (1998).
Rosa, M. G. P. & Tweedale, R. The dorsomedial visual areas in new world and old world monkeys: homology and function. Eur. J. Neurosci. 13, 421–427 (2001).
Marshall, M. P. Strabismus care: past, present and future. Documenta Ophthalmologica V34, 301–315 (1973).
Hubel, D. H. & Wiesel, T. N. Functional architecture of macaque monkey visual-cortex. Proc. R. Soc. Lond. B Biol. Sci. 198, 1–59 (1977).
Hubel, D. H. & Wiesel, T. N. Period of susceptibility to physiological effects of unilateral eye closure in kittens. J. Physiol. 206, 419–436 (1970).
Levi, D. M. Visual processing in amblyopia: human studies. Strabismus 14, 11–19 (2006).
Kiorpes, L. Visual processing in amblyopia: animal studies. Strabismus 14, 3–10 (2006).
Davis, A. P. et al. Electrophysiological and psychophysical differences between early- and late-onset strabismic amblyopia. Invest. Ophthalmol. Vis. Sci. 44, 610–617 (2003).
Anderson, S. J. & Swettenham, J. B. Neuroimaging in human amblyopia. Strabismus 14, 21–35 (2006).
di Stefano, M. & Gargini, C. Cortical binocularity in convergent strabismus after section of the optic chiasm. Exp. Brain Res. 147, 64–70 (2002).
Harwerth, R. S., Smith, E. L., Crawford, M. L. J. & vonNoorden, G. K. Stereopsis and disparity vergence in monkeys with subnormal binocular vision. Vision Res. 37, 483–493 (1997).
Levi, D. M. & Polat, U. Neural plasticity in adults with amblyopia. Proc. Natl Acad. Sci. USA 93, 6830–6834 (1996).
Levi, D. M., Polat, U. & Hu, Y. S. Improvement in vernier acuity in adults with amblyopia. Practice makes better. Invest. Ophthalmol. Vis. Sci. 38, 1493–1510 (1997).
Sacks, O. L. Stereo Sue: why two eyes are better than one. The New Yorker 82, 64–93 (2006).
Jaschinski, W., Konig, M., Schmidt, R. & Methling, D. Vergence dynamics and variability of fixation disparity in dyslexic children. Klin. Monatsbl. Augenheilkd. 221, 854–861 (2004).
Stein, J. F., Richardson, A. J. & Fowler, M. S. Monocular occlusion can improve binocular control and reading in dyslexics. Brain 123, 164–170 (2000).
Evans, B. J. W., Drasdo, N. & Richards, I. L. Dyslexia: the link with visual deficits. Ophthalmic Physiol. Opt. 16, 3–10 (1996).
Livingstone, M. S., Rosen, G. D., Drislane, F. W. & Galaburda, A. M. Physiological and anatomical evidence for a magnocellular defect in developmental dyslexia. Proc. Natl Acad. Sci. USA 88, 7943–7947 (1991).
Silvanto, J., Cowey, A., Lavie, N. & Walsh, V. Striate cortex (V1) activity gates awareness of motion. Nature Neurosci. 8, 143–144 (2005).
Driver, J. & Mattingley, J. B. Parietal neglect and visual awareness. Nature Neurosci. 1, 17–22 (1998).
Rees, G., Kreiman, G. & Koch, C. Neural correlates of consciousness in humans. Nature Rev. Neurosci. 3, 261–270 (2002).
Halligan, P. W. & Marshall, J. C. Left neglect for near but not far space in man. Nature 350, 498–500 (1991).
Nishihara, H. K. Practical real-time imaging stereo matcher. Opt. Eng. 23, 536–545 (1984).
Adelson, E. H. & Bergen, J. R. Spatiotemporal energy models for the perception of motion. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 2, 284–299 (1985).
Prince, S. J. D., Pointon, A. D., Cumming, B. G. & Parker, A. J. Quantitative analysis of the responses of V1 neurons to horizontal disparity in dynamic random-dot stereograms. J. Neurophysiol. 87, 191–208 (2002).
Zigmond, M. J., Bloom, F. E., Landis, S. C., Roberts, J. L. & Squire, L. R. Fundamental Neuroscience (Academic, San Diego, 1999).
Acknowledgements
This work was supported by research grants from the Wellcome Trust and the James S. McDonnell Foundation. The author holds a Royal Society Wolfson Research Merit Award. I should like to thank H. Bridge, B. Cumming, I. Fujita, A. Glennerster, K. Krug and L. Minini for their time and patience in providing comments on earlier drafts of this article. I would also like to thank B. Cumming, G. DeAngelis, I. Fujita and A. Takemura for generously providing access to unpublished data values in the preparation of Figure 1 and elsewhere. I am grateful to A.T. for kindly recalculating the ratio of anticorrelated to correlated responses for cortical area MST from the data described in their paper52. The section of the macaque monkey brain shown in Figure 4 was prepared by K. Krug, Dept. Physiology, Anatomy & Genetics, Oxford, UK.
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Glossary
- Tuning function
-
A set of measurements that summarize the selectivity of a sensory neuron for some particular aspect of the stimulus, such as orientation, visual motion or binocular disparity.
- Disparity selectivity
-
The selectivity of a visual neuron for binocular disparity, usually summarized in the form of a tuning function.
- Magnocellular pathway
-
Distinct pathway from retina to cortex that has synaptic relays in the lateral geniculate nucleus, which arrive in layers that consist of large cell bodies. Magnocellular neurons do not transmit colour information and have fast responses.
- Parvocellular pathway
-
Distinct pathway from retina to cortex that has synaptic relays in the lateral geniculate nucleus, which arrive in layers that consist of small cell bodies. Parvocellular neurons carry information about colour and fine spatial detail, and have slower responses.
- Stereopsis
-
The sense of depth that is generated when the brain combines information from the left and right eyes.
- Coarse stereopsis
-
Binocular depth perception outside the range for stereoscopic acuity, processing disparities greater than 0.3 degrees in the human fovea.
- Fine stereopsis
-
Binocular depth perception responsible for stereoscopic acuity and normally taken as processing disparities within the range of 0.3 degrees in the human fovea. This range is larger at greater visual eccentricities.
- Single-unit recording
-
An experimental method of studying the nervous system in which the electrical impulses from single nerve cells are measured and analysed.
- Visual eccentricity
-
The location of an object in visual space with respect to the line of sight from the eye, usually measured in degrees of angle between the line of sight and a line projecting from the eye to the object. It also refers to the location of a visual receptive field projected out into visual space.
- Fovea
-
The most central region of the retina, which contains a high concentration of cone photoreceptors and forms a slight depression in the retinal surface. It projects into visual space to a region about 5 degrees across, equivalent to an object 8.7cm in diameter viewed from 1m away.
- Extrastriate cortex
-
A belt of visually responsive areas of cortex surrounding the primary visual cortex.
- Random-dot stereograms
-
A pair of images, one for each eye, composed of picture elements that are randomly either black or white. When combined, stereopsis reveals a previously hidden figure, which the brain detects by matching up the picture elements presented independently to each eye.
- Correlation detection
-
A measurement that provides a simple summary of the similarity between two sets of data. In this context, the two data sets are the neural signals arising from small patches of retina at closely similar locations in the left and right eyes.
- Saccadic eye movement
-
The transfer of gaze from one location to another by rapid, coordinated movement of the eyes.
- Simple cell
-
Neuron of the primary visual cortex, the visual receptive field of which is orientation selective and can be divided into spatially distinct regions that are mutually antagonistic and in which light either enhances or suppresses action potentials from the neuron.
- Complex cell
-
Neuron of the primary visual cortex, the visual receptive field of which is orientation selective but, unlike simple cells, cannot be divided into spatially distinct regions.
- Energy model
-
A computational model of visual neuronal processing that consists of a quadrature pair of linear filters followed by the nonlinear operation of squaring and combination across those filters.
- Even-symmetric function
-
A mathematical function for which F(−x) = F(x), where x>0.
- Odd-symmetric function
-
A mathematical function for which F(−x) = −F(x), where x>0.
- Quadrature pair
-
Pair of functions which have an identical Fourier amplitude spectrum in the frequency domain, but have a Fourier phase spectrum that differs by 90 degrees at all frequencies.
- Near–far discrimination task
-
Visual task that requires the individual to judge whether a visual feature (such as a cluster of dots) is nearer or further than the distance to the visual fixation point.
- Squint
-
A human clinical condition, manifest when a person tries to look at a target with both eyes, but the line of sight of one eye consistently deviates from the target while the other eye is successfully aligned.
- Amblyopia
-
Poor vision through an eye that is otherwise physically healthy, but has faulty connections with the rest of the brain; there is disrupted transmission of the visual image, most often due to adverse events during a developmental critical period. It affects 2–5% of the global population.
- Esotropia
-
Form of squint in which the deviating eye turns inwards, towards the nose (in exotropia the eye turns outwards, away from the nose).
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Parker, A. Binocular depth perception and the cerebral cortex. Nat Rev Neurosci 8, 379–391 (2007). https://doi.org/10.1038/nrn2131
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DOI: https://doi.org/10.1038/nrn2131
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The effect of different depth planes during a manual tracking task in three-dimensional virtual reality space
Scientific Reports (2023)
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Low frequency oscillations during hand laterality judgment task with and without personal perspectives: a preliminary study
Cognitive Neurodynamics (2023)
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Cortical Deficits are Correlated with Impaired Stereopsis in Patients with Strabismus
Neuroscience Bulletin (2023)
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Scene-relative object motion biases depth percepts
Scientific Reports (2022)