Abstract

The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.

Author affiliations

1. The Institute for Advanced Study, Princeton, New Jersey, USA.
2. The BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, USA.
3. The Mathematics Department, Rutgers University, Piscataway, New Jersey, USA.
4. The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

Correspondence to: Todd Riley^1,2 Email: triley@ias.edu