Abstract

Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.

Author affiliations

1. Department of Cell Biology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands. Email: a.akhmanova@erasmusmc.nl
2. Biomolecular Research, Structural Biology, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland. Email: michel.steinmetz@psi.ch

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